Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling

Guolun Wang; Bingqiang Wen; Zicheng Deng; Yufang Zhang; Olena A. Kolesnichenko; Vladimir Ustiyan; Arun Pradhan; Tanya V. Kalin; Vladimir V. Kalinichenko

doi:10.1038/s41467-022-29746-y

Nature Communications (Apr 2022)

Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling

Guolun Wang,
Bingqiang Wen,
Zicheng Deng,
Yufang Zhang,
Olena A. Kolesnichenko,
Vladimir Ustiyan,
Arun Pradhan,
Tanya V. Kalin,
Vladimir V. Kalinichenko

Affiliations

Guolun Wang: Center for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical Center
Bingqiang Wen: Center for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical Center
Zicheng Deng: Center for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical Center
Yufang Zhang: Center for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical Center
Olena A. Kolesnichenko: Center for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical Center
Vladimir Ustiyan: Center for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical Center
Arun Pradhan: Center for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical Center
Tanya V. Kalin: Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center
Vladimir V. Kalinichenko: Center for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical Center

DOI: https://doi.org/10.1038/s41467-022-29746-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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The molecular mechanisms through which pulmonary endothelial progenitor cells stimulate lung angiogenesis are not clear. Here, authors show that these cells stimulate the growth of alveolar capillaries and alveoli of newborn mice through FOXF1 and FLI1 nuclear protein-activation of the BMP9/ACVRL1/SMAD1 signaling pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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