Nature Communications (Oct 2023)
Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways
- Xu Lin,
- Hong-Mei Xiao,
- Hui-Min Liu,
- Wan-Qiang Lv,
- Jonathan Greenbaum,
- Rui Gong,
- Qiang Zhang,
- Yuan-Cheng Chen,
- Cheng Peng,
- Xue-Juan Xu,
- Dao-Yan Pan,
- Zhi Chen,
- Zhang-Fang Li,
- Rou Zhou,
- Xia-Fang Wang,
- Jun-Min Lu,
- Zeng-Xin Ao,
- Yu-Qian Song,
- Yin-Hua Zhang,
- Kuan-Jui Su,
- Xiang-He Meng,
- Chang-Li Ge,
- Feng-Ye Lv,
- Zhe Luo,
- Xing-Ming Shi,
- Qi Zhao,
- Bo-Yi Guo,
- Neng-Jun Yi,
- Hui Shen,
- Christopher J. Papasian,
- Jie Shen,
- Hong-Wen Deng
Affiliations
- Xu Lin
- Shunde Hospital of Southern Medical University (The First People’s Hospital of Shunde)
- Hong-Mei Xiao
- Center of System Biology, Data Information and Reproductive Health, School of Basic Medical Science, Central South University
- Hui-Min Liu
- Center of System Biology, Data Information and Reproductive Health, School of Basic Medical Science, Central South University
- Wan-Qiang Lv
- Center of System Biology, Data Information and Reproductive Health, School of Basic Medical Science, Central South University
- Jonathan Greenbaum
- Tulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University
- Rui Gong
- Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University
- Qiang Zhang
- Tulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University
- Yuan-Cheng Chen
- Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University
- Cheng Peng
- Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University
- Xue-Juan Xu
- Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University
- Dao-Yan Pan
- Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University
- Zhi Chen
- Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University
- Zhang-Fang Li
- Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University
- Rou Zhou
- Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University
- Xia-Fang Wang
- Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University
- Jun-Min Lu
- Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University
- Zeng-Xin Ao
- Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University
- Yu-Qian Song
- Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University
- Yin-Hua Zhang
- Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University
- Kuan-Jui Su
- Tulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University
- Xiang-He Meng
- Tulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University
- Chang-Li Ge
- LC-Bio Technologies (Hangzhou) CO., LTD.
- Feng-Ye Lv
- LC-Bio Technologies (Hangzhou) CO., LTD.
- Zhe Luo
- Tulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University
- Xing-Ming Shi
- Departments of Neuroscience & Regenerative Medicine and Orthopaedic Surgery, Medical College of Georgia, Augusta University
- Qi Zhao
- Department of Preventive Medicine, College of Medicine, University of Tennessee Health Science Center
- Bo-Yi Guo
- Department of Biostatistics, University of Alabama at Birmingham
- Neng-Jun Yi
- Department of Biostatistics, University of Alabama at Birmingham
- Hui Shen
- Tulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University
- Christopher J. Papasian
- Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City
- Jie Shen
- Shunde Hospital of Southern Medical University (The First People’s Hospital of Shunde)
- Hong-Wen Deng
- Tulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University
- DOI
- https://doi.org/10.1038/s41467-023-42005-y
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 17
Abstract
Abstract Although the gut microbiota has been reported to influence osteoporosis risk, the individual species involved, and underlying mechanisms, remain largely unknown. We performed integrative analyses in a Chinese cohort of peri-/post-menopausal women with metagenomics/targeted metabolomics/whole-genome sequencing to identify novel microbiome-related biomarkers for bone health. Bacteroides vulgatus was found to be negatively associated with bone mineral density (BMD), which was validated in US white people. Serum valeric acid (VA), a microbiota derived metabolite, was positively associated with BMD and causally downregulated by B. vulgatus. Ovariectomized mice fed B. vulgatus demonstrated increased bone resorption and poorer bone micro-structure, while those fed VA demonstrated reduced bone resorption and better bone micro-structure. VA suppressed RELA protein production (pro-inflammatory), and enhanced IL10 mRNA expression (anti-inflammatory), leading to suppressed maturation of osteoclast-like cells and enhanced maturation of osteoblasts in vitro. The findings suggest that B. vulgatus and VA may represent promising targets for osteoporosis prevention/treatment.
