Nature Communications (Sep 2021)

Promoter-proximal elongation regulates transcription in archaea

  • Fabian Blombach,
  • Thomas Fouqueau,
  • Dorota Matelska,
  • Katherine Smollett,
  • Finn Werner

DOI
https://doi.org/10.1038/s41467-021-25669-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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Transcription in archaea is known to be regulated through the recruitment of RNA polymerase to promoters. Here, the authors show that the archaeon Saccharolobus solfataricus regulates transcription globally through a rate-limiting promoter-proximal elongation step.