Nature Communications (Mar 2017)
Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20
- Gan Liu,
- Luting Zhou,
- Hai Zhang,
- Rong Chen,
- Ye Zhang,
- Ling Li,
- Jun-Yu Lu,
- Hui Jiang,
- Dong Liu,
- Shasha Qi,
- Ying-Ming Jiang,
- Kai Yin,
- Zhifang Xie,
- Yuguang Shi,
- Yong Liu,
- Xuetao Cao,
- Yu-Xia Chen,
- Dajin Zou,
- Weiping J. Zhang
Affiliations
- Gan Liu
- Department of Pathophysiology, Second Military Medical University
- Luting Zhou
- Department of Pathophysiology, Second Military Medical University
- Hai Zhang
- Department of Pathophysiology, Second Military Medical University
- Rong Chen
- Department of Pathophysiology, Second Military Medical University
- Ye Zhang
- Department of Pathophysiology, Second Military Medical University
- Ling Li
- Department of Pathophysiology, Second Military Medical University
- Jun-Yu Lu
- Department of Pathophysiology, Second Military Medical University
- Hui Jiang
- Department of Pathophysiology, Second Military Medical University
- Dong Liu
- Department of Pathophysiology, Second Military Medical University
- Shasha Qi
- Department of Pathophysiology, Second Military Medical University
- Ying-Ming Jiang
- National Key Laboratory of Medical Immunology, Second Military Medical University
- Kai Yin
- Obesity & Diabetes Research Center, Second Military Medical University
- Zhifang Xie
- Department of Pathophysiology, Second Military Medical University
- Yuguang Shi
- Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio
- Yong Liu
- Institute of Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Science
- Xuetao Cao
- National Key Laboratory of Medical Immunology, Second Military Medical University
- Yu-Xia Chen
- Department of Pathophysiology, Second Military Medical University
- Dajin Zou
- Obesity & Diabetes Research Center, Second Military Medical University
- Weiping J. Zhang
- Department of Pathophysiology, Second Military Medical University
- DOI
- https://doi.org/10.1038/ncomms14824
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
De novo lipogenesis is tightly controlled by hormonal and nutritional signals and plays an important role in energy homoeostasis. Here, Liu et al. show that zinc finger protein ZBTB20 regulates the expression of key glycolytic and lipogenic genes by modulating ChREBP expression and transcriptional activity.
