Nature Communications (Apr 2016)
Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming
- Thomas Moreau,
- Amanda L. Evans,
- Louella Vasquez,
- Marloes R. Tijssen,
- Ying Yan,
- Matthew W. Trotter,
- Daniel Howard,
- Maria Colzani,
- Meera Arumugam,
- Wing Han Wu,
- Amanda Dalby,
- Riina Lampela,
- Guenaelle Bouet,
- Catherine M. Hobbs,
- Dean C. Pask,
- Holly Payne,
- Tatyana Ponomaryov,
- Alexander Brill,
- Nicole Soranzo,
- Willem H. Ouwehand,
- Roger A. Pedersen,
- Cedric Ghevaert
Affiliations
- Thomas Moreau
- Department of Haematology, University of Cambridge and NHS Blood and Transplant
- Amanda L. Evans
- Department of Haematology, University of Cambridge and NHS Blood and Transplant
- Louella Vasquez
- Human Genetics, Wellcome Trust Sanger Institute, Genome Campus
- Marloes R. Tijssen
- Department of Haematology, University of Cambridge and NHS Blood and Transplant
- Ying Yan
- Human Genetics, Wellcome Trust Sanger Institute, Genome Campus
- Matthew W. Trotter
- Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Surgery, The Anne McLaren Laboratory, University of Cambridge
- Daniel Howard
- Department of Haematology, University of Cambridge and NHS Blood and Transplant
- Maria Colzani
- Department of Haematology, University of Cambridge and NHS Blood and Transplant
- Meera Arumugam
- Department of Haematology, University of Cambridge and NHS Blood and Transplant
- Wing Han Wu
- Department of Haematology, University of Cambridge and NHS Blood and Transplant
- Amanda Dalby
- Department of Haematology, University of Cambridge and NHS Blood and Transplant
- Riina Lampela
- Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute
- Guenaelle Bouet
- Department of Haematology, University of Cambridge and NHS Blood and Transplant
- Catherine M. Hobbs
- Department of Haematology, University of Cambridge and NHS Blood and Transplant
- Dean C. Pask
- Department of Haematology, University of Cambridge and NHS Blood and Transplant
- Holly Payne
- Institute of Cardiovascular Sciences, University of Birmingham
- Tatyana Ponomaryov
- Institute of Cardiovascular Sciences, University of Birmingham
- Alexander Brill
- Institute of Cardiovascular Sciences, University of Birmingham
- Nicole Soranzo
- Human Genetics, Wellcome Trust Sanger Institute, Genome Campus
- Willem H. Ouwehand
- Department of Haematology, University of Cambridge and NHS Blood and Transplant
- Roger A. Pedersen
- Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Surgery, The Anne McLaren Laboratory, University of Cambridge
- Cedric Ghevaert
- Department of Haematology, University of Cambridge and NHS Blood and Transplant
- DOI
- https://doi.org/10.1038/ncomms11208
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
Platelets are blood circulating corpuscles generated from megakaryocytes that initiate wound healing. Here, Moreau et al. describe a way of producing large quantities of megakaryocytes from human pluripotent stem cells in the laboratory, moving us a step closer to manufacturing transfusion products.
