Nature Communications (Apr 2016)
Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells
- Isabel Meininger,
- Richard A. Griesbach,
- Desheng Hu,
- Torben Gehring,
- Thomas Seeholzer,
- Arianna Bertossi,
- Jan Kranich,
- Andrea Oeckinghaus,
- Andrea C. Eitelhuber,
- Ute Greczmiel,
- Andreas Gewies,
- Marc Schmidt-Supprian,
- Jürgen Ruland,
- Thomas Brocker,
- Vigo Heissmeyer,
- Florian Heyd,
- Daniel Krappmann
Affiliations
- Isabel Meininger
- Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München—German Research Center for Environmental Health
- Richard A. Griesbach
- Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München—German Research Center for Environmental Health
- Desheng Hu
- Research Unit Molecular Immune Regulation, Helmholtz Zentrum München—German Research Center for Environmental Health
- Torben Gehring
- Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München—German Research Center for Environmental Health
- Thomas Seeholzer
- Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München—German Research Center for Environmental Health
- Arianna Bertossi
- Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München—German Research Center for Environmental Health
- Jan Kranich
- Institute for Immunology, Biomedical Center Munich, LMU Munich
- Andrea Oeckinghaus
- Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München—German Research Center for Environmental Health
- Andrea C. Eitelhuber
- Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München—German Research Center for Environmental Health
- Ute Greczmiel
- Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München—German Research Center for Environmental Health
- Andreas Gewies
- Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München
- Marc Schmidt-Supprian
- German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ)
- Jürgen Ruland
- Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München
- Thomas Brocker
- Institute for Immunology, Biomedical Center Munich, LMU Munich
- Vigo Heissmeyer
- Research Unit Molecular Immune Regulation, Helmholtz Zentrum München—German Research Center for Environmental Health
- Florian Heyd
- Free University Berlin, Institute of Chemistry and Biochemistry, RNA Biochemistry
- Daniel Krappmann
- Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München—German Research Center for Environmental Health
- DOI
- https://doi.org/10.1038/ncomms11292
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
MALT1 regulates NFκB signalling both as a scaffolding protein and as a protease. Here the authors show that during T cell activation the expression of MALT1 gene switches to an alternatively spliced variant, which increases TCR signal transduction due to enhanced TRAF6 binding.
