Nature Communications (Apr 2022)
Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery
- Tian Zhou,
- Xinyi Zhu,
- Zhizhong Ye,
- Yong-Fei Wang,
- Chao Yao,
- Ning Xu,
- Mi Zhou,
- Jianyang Ma,
- Yuting Qin,
- Yiwei Shen,
- Yuanjia Tang,
- Zhihua Yin,
- Hong Xu,
- Yutong Zhang,
- Xiaoli Zang,
- Huihua Ding,
- Wanling Yang,
- Ya Guo,
- John B. Harley,
- Bahram Namjou,
- Kenneth M. Kaufman,
- Leah C. Kottyan,
- Matthew T. Weirauch,
- Guojun Hou,
- Nan Shen
Affiliations
- Tian Zhou
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM)
- Xinyi Zhu
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM)
- Zhizhong Ye
- Shenzhen Futian Hospital for Rheumatic Diseases
- Yong-Fei Wang
- Department of Paediatrics and Adolescent Medicine, The University of Hong Kong
- Chao Yao
- Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences (SIBS), University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS)
- Ning Xu
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM)
- Mi Zhou
- Sheng Yushou Center of Cell Biology and Immunology, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University (SJTU)
- Jianyang Ma
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM)
- Yuting Qin
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM)
- Yiwei Shen
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM)
- Yuanjia Tang
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM)
- Zhihua Yin
- Shenzhen Futian Hospital for Rheumatic Diseases
- Hong Xu
- Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM)
- Yutong Zhang
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM)
- Xiaoli Zang
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM)
- Huihua Ding
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM)
- Wanling Yang
- Department of Paediatrics and Adolescent Medicine, The University of Hong Kong
- Ya Guo
- Sheng Yushou Center of Cell Biology and Immunology, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University (SJTU)
- John B. Harley
- US Department of Veterans Affairs Medical Center
- Bahram Namjou
- Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center
- Kenneth M. Kaufman
- Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center
- Leah C. Kottyan
- Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center
- Matthew T. Weirauch
- Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center
- Guojun Hou
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM)
- Nan Shen
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM)
- DOI
- https://doi.org/10.1038/s41467-022-29514-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
The functional effects of genetic loci associated with autoimmune disease are not well understood. By dissecting an autoimmune disease genetic locus, the authors define an immune cell-type-specific enhancer and the molecular mechanisms underlying the dysregulation of IRF8 expression by lupus risk variants.
