Meta-analysis of predictors of healthcare-associated Clostridioides difficile infection

Jesse Fajnzylber; William M. Patterson; Neil Nero; Adrian V. Hernandez; Abhishek Deshpande

doi:10.1017/ash.2024.413

Antimicrobial Stewardship & Healthcare Epidemiology (Jan 2024)

Meta-analysis of predictors of healthcare-associated Clostridioides difficile infection

Jesse Fajnzylber,
William M. Patterson,
Neil Nero,
Adrian V. Hernandez,
Abhishek Deshpande

Affiliations

Jesse Fajnzylber: ORCiD; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA
William M. Patterson: ORCiD; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA
Neil Nero: ORCiD; Education Institute, Floyd D. Loop Alumni Library, Cleveland Clinic, Cleveland, OH, USA
Adrian V. Hernandez: ORCiD; Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, CT, USA Unidad de Revisiones Sistemáticas y Meta-análisis (URSIGET), Vicerrectorado de Investigación, Universidad San Ignacio de Loyola (USIL), Lima, Peru
Abhishek Deshpande: ORCiD; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA Center for Value-Based Care Research, Primary Care Institute, Cleveland Clinic, Cleveland, OH, USA Department of Infectious Diseases, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA

DOI: https://doi.org/10.1017/ash.2024.413
Journal volume & issue: Vol. 4

Abstract

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Our systematic review and meta-analysis of 40 studies (n = 3,905,559) identified gastric acid suppressants, recent hospitalization, antibiotic exposure, and certain comorbidities as independent predictors of healthcare-associated Clostridioides difficile infection (HA-CDI) among adult inpatients. Targeted antibiotic stewardship and judicious use of gastric acid suppressants can reduce the incidence of HA-CDI.

Published in Antimicrobial Stewardship & Healthcare Epidemiology

ISSN: 2732-494X (Online)
Publisher: Cambridge University Press
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.cambridge.org/core/journals/antimicrobial-stewardship-and-healthcare-epidemiology

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