Comparative efficacy of cephradine-loaded silver and gold nanoparticles against resistant human pathogens

Ajmal Khan; Humera Jabeen; Touqeer Ahmad; Najeeb Ur Rehman; Saleha Suleman Khan; Huma Shareef; Rizwana Sarwar; Saira Yahya; Nusrat Hussain; Jalal Uddin; Javid Hussain; Ahmed Al-Harrasi

doi:10.1080/21691401.2022.2144340

Artificial Cells, Nanomedicine, and Biotechnology (Dec 2022)

Comparative efficacy of cephradine-loaded silver and gold nanoparticles against resistant human pathogens

Ajmal Khan,
Humera Jabeen,
Touqeer Ahmad,
Najeeb Ur Rehman,
Saleha Suleman Khan,
Huma Shareef,
Rizwana Sarwar,
Saira Yahya,
Nusrat Hussain,
Jalal Uddin,
Javid Hussain,
Ahmed Al-Harrasi

Affiliations

Ajmal Khan: Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman
Humera Jabeen: Department of Chemistry, Sardar Bahadur Khan Women’s University, Quetta, Pakistan
Touqeer Ahmad: Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman
Najeeb Ur Rehman: Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman
Saleha Suleman Khan: Department of Chemistry, Sardar Bahadur Khan Women’s University, Quetta, Pakistan
Huma Shareef: Department of Pharmacognosy, Faculty of Pharmacy, Jinnah Sindh Medical University, Karachi, Pakistan
Rizwana Sarwar: Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, Pakistan
Saira Yahya: Department of Biosciences, Shaheed Zulfikar Ali Bhutto Institute of Science and Technology, Karachi, Pakistan
Nusrat Hussain: Department of Chemistry, University of Baltistan Skardu, Skardu, Pakistan
Jalal Uddin: Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia
Javid Hussain: Department of Biological Sciences and Chemistry, University of Nizwa, Nizwa, Sultanate of Oman
Ahmed Al-Harrasi: Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman

DOI: https://doi.org/10.1080/21691401.2022.2144340
Journal volume & issue: Vol. 50, no. 1
pp. 312 – 321

Abstract

Read online

Infections caused by drug-resistant bacteria are major health concerns worldwide. We successfully synthesized cephradine gold nanoparticles (Ceph-Au NPs) and cephradine silver nanoparticles (Ceph-Ag NPs) and compared their efficacy against resistant human pathogens. X-Ray diffraction (XRD), Atomic Force Microscopy (AFM) and Transmission Electron Microscopy (TEM) results showed that average particle size of Ceph-Au NPs and Ceph-Ag NPs were 7 and 12 nm, respectively. Fourier Transform Infra-red spectroscopy (FTIR) spectra revealed the conjugation of –NH2 and –OH functional moieties with the nanoparticle (NP) surfaces. These NPs significantly inhibited the biofilm of Streptococcus mutans (S. mutans) and methicillin-resistant Staphylococcus aureus (MRSA) in the range of 61.25–250 µg/mL. Ceph-Au NPs are more active than Ceph-Ag NPs and can be used to treat the diseases associated with MRSA and S. mutans.

Published in Artificial Cells, Nanomedicine, and Biotechnology

ISSN: 2169-1401 (Print); 2169-141X (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Medicine: Medicine (General): Medical technology
Website: https://www.tandfonline.com/journals/ianb

About the journal

Abstract

Keywords