Cardioprotective effect of Erythrina stricta leaves on isoproterenol-induced myocardial infarction in rat

Abstract

The cardioprotective activity of Erythrina stricta leaves against isoproterenol-induced myocardial infarction was studied. Wistar albino rats were pretreated with leaf extract (200 mg/kg) daily for 28 days. After treatment, isoproterenol (8.5 mg/kg body weight, orally) was injected to rats at an interval of 24 hours for two days to induce myocardial injury. Cardioprotection was investigated by estimating the activities of serum aminotransferase, lactate dehydrogenase and creatinine kinase. Anti-oxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and thiobarbituric acid reactive substances were determined. The activities of serum marker enzymes were increased significantly (p<0.05) in isoproterenol-induced rats. E. stricta leaf extract showed a decrease in serum enzyme levels and increase of antioxidant status. The results were confirmed by histopathological evidences. The present study concludes that E. stricta leaf extract has a prophylactic value in myocardial infarction.

Keywords

• Cardioprotective
• Erythrina stricta
• Lipid peroxidation
• Myocardial infarction