Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection

Najmeh Bozorgmehr; Siavash Mashhouri; Eliana Perez Rosero; Lai Xu; Shima Shahbaz; Wendy Sligl; Mohammed Osman; Demetrios J. Kutsogiannis; Erika MacIntyre; Conar R. O’Neil; Shokrollah Elahi

doi:10.1128/mBio.00384-21

mBio (Jun 2021)

Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection

Najmeh Bozorgmehr,
Siavash Mashhouri,
Eliana Perez Rosero,
Lai Xu,
Shima Shahbaz,
Wendy Sligl,
Mohammed Osman,
Demetrios J. Kutsogiannis,
Erika MacIntyre,
Conar R. O’Neil,
Shokrollah Elahi

Affiliations

Najmeh Bozorgmehr: School of Dentistry, Division of Foundational Sciences, University of Alberta, Edmonton, Alberta, Canada
Siavash Mashhouri: School of Dentistry, Division of Foundational Sciences, University of Alberta, Edmonton, Alberta, Canada
Eliana Perez Rosero: School of Dentistry, Division of Foundational Sciences, University of Alberta, Edmonton, Alberta, Canada
Lai Xu: School of Dentistry, Division of Foundational Sciences, University of Alberta, Edmonton, Alberta, Canada
Shima Shahbaz: School of Dentistry, Division of Foundational Sciences, University of Alberta, Edmonton, Alberta, Canada
Wendy Sligl: Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Mohammed Osman: Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Demetrios J. Kutsogiannis: Department of Critical Care Medicine, University of Alberta, Edmonton, Alberta, Canada
Erika MacIntyre: Misericordia Community Hospital, Edmonton, Alberta, Canada
Conar R. O’Neil: Division of Infectious Diseases, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
Shokrollah Elahi: ORCiD; School of Dentistry, Division of Foundational Sciences, University of Alberta, Edmonton, Alberta, Canada

DOI: https://doi.org/10.1128/mBio.00384-21
Journal volume & issue: Vol. 12, no. 3

Abstract

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The outbreak of SARS-CoV-2 infection has enormously impacted our lives. Clinical evidence has implicated the emergence of cytokine release syndrome as the prominent cause of mortality in COVID-19 patients.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal