Nature Communications (Mar 2020)

Pretreatment tumor-related leukocytosis misleads positron emission tomography-computed tomography during lymph node staging in gynecological malignancies

  • Seiji Mabuchi,
  • Naoko Komura,
  • Tomoyuki Sasano,
  • Kotaro Shimura,
  • Eriko Yokoi,
  • Katsumi Kozasa,
  • Hiromasa Kuroda,
  • Ryoko Takahashi,
  • Mahiru Kawano,
  • Yuri Matsumoto,
  • Hiroki Kato,
  • Jun Hatazawa,
  • Tadashi Kimura

DOI
https://doi.org/10.1038/s41467-020-15186-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Modern imaging techniques can detect cancer cells in the lymph nodes of cancer patients. In this study, the authors show that tumour related leukocytosis, a phenomenon where leukocytes are increased in number, can lead to the false positive detection of cancer cells in lymph nodes.