Caffeic acid mitigates myocardial fibrosis and improves heart function in post-myocardial infarction by inhibiting transforming growth factor-β receptor 1 signaling pathways

Weihao Jiang; Bo Deng; Mengting Xie; Yunting Feng; Xiaoli Jiang; Bo Yang; Zhangbin Tan; Hongbin Ou; Yongzhen Tan; Shaojun Liu; Shuangwei Zhang; Jingzhi Zhang; Yingchun Zhou; Weiwei Wu; Bin Liu

Biomedicine & Pharmacotherapy (Aug 2024)

Caffeic acid mitigates myocardial fibrosis and improves heart function in post-myocardial infarction by inhibiting transforming growth factor-β receptor 1 signaling pathways

Weihao Jiang,
Bo Deng,
Mengting Xie,
Yunting Feng,
Xiaoli Jiang,
Bo Yang,
Zhangbin Tan,
Hongbin Ou,
Yongzhen Tan,
Shaojun Liu,
Shuangwei Zhang,
Jingzhi Zhang,
Yingchun Zhou,
Weiwei Wu,
Bin Liu

Affiliations

Weihao Jiang: Department of Traditional Chinese Medicine, Guangzhou Institute of Cardiovascular Disease, State Key Laboratory of Respiratory Disease, Institute of Integration of Traditional and Western Medicine of Guangzhou Medical University, The Second Affiliated Hospital of Guangzhou Medical University, No.250 Changgangdong Road, Guangzhou 510260, China
Bo Deng: Department of Traditional Chinese Medicine, Guangzhou Institute of Cardiovascular Disease, State Key Laboratory of Respiratory Disease, Institute of Integration of Traditional and Western Medicine of Guangzhou Medical University, The Second Affiliated Hospital of Guangzhou Medical University, No.250 Changgangdong Road, Guangzhou 510260, China
Mengting Xie: Department of Traditional Chinese Medicine, Guangzhou Institute of Cardiovascular Disease, State Key Laboratory of Respiratory Disease, Institute of Integration of Traditional and Western Medicine of Guangzhou Medical University, The Second Affiliated Hospital of Guangzhou Medical University, No.250 Changgangdong Road, Guangzhou 510260, China
Yunting Feng: Department of Traditional Chinese Medicine, Guangzhou Institute of Cardiovascular Disease, State Key Laboratory of Respiratory Disease, Institute of Integration of Traditional and Western Medicine of Guangzhou Medical University, The Second Affiliated Hospital of Guangzhou Medical University, No.250 Changgangdong Road, Guangzhou 510260, China
Xiaoli Jiang: Department of Traditional Chinese Medicine, Guangzhou Institute of Cardiovascular Disease, State Key Laboratory of Respiratory Disease, Institute of Integration of Traditional and Western Medicine of Guangzhou Medical University, The Second Affiliated Hospital of Guangzhou Medical University, No.250 Changgangdong Road, Guangzhou 510260, China
Bo Yang: Department of Traditional Chinese Medicine, Guangzhou Institute of Cardiovascular Disease, State Key Laboratory of Respiratory Disease, Institute of Integration of Traditional and Western Medicine of Guangzhou Medical University, The Second Affiliated Hospital of Guangzhou Medical University, No.250 Changgangdong Road, Guangzhou 510260, China
Zhangbin Tan: Department of Traditional Chinese Medicine, Guangzhou Institute of Cardiovascular Disease, State Key Laboratory of Respiratory Disease, Institute of Integration of Traditional and Western Medicine of Guangzhou Medical University, The Second Affiliated Hospital of Guangzhou Medical University, No.250 Changgangdong Road, Guangzhou 510260, China
Hongbin Ou: Department of Traditional Chinese Medicine, Guangzhou Institute of Cardiovascular Disease, State Key Laboratory of Respiratory Disease, Institute of Integration of Traditional and Western Medicine of Guangzhou Medical University, The Second Affiliated Hospital of Guangzhou Medical University, No.250 Changgangdong Road, Guangzhou 510260, China
Yongzhen Tan: Department of Traditional Chinese Medicine, Guangzhou Institute of Cardiovascular Disease, State Key Laboratory of Respiratory Disease, Institute of Integration of Traditional and Western Medicine of Guangzhou Medical University, The Second Affiliated Hospital of Guangzhou Medical University, No.250 Changgangdong Road, Guangzhou 510260, China
Shaojun Liu: Guangzhou Institute of Cardiovascular Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
Shuangwei Zhang: Department of Traditional Chinese Medicine, Guangzhou Institute of Cardiovascular Disease, State Key Laboratory of Respiratory Disease, Institute of Integration of Traditional and Western Medicine of Guangzhou Medical University, The Second Affiliated Hospital of Guangzhou Medical University, No.250 Changgangdong Road, Guangzhou 510260, China
Jingzhi Zhang: Department of Traditional Chinese Medicine, Guangzhou Institute of Cardiovascular Disease, State Key Laboratory of Respiratory Disease, Institute of Integration of Traditional and Western Medicine of Guangzhou Medical University, The Second Affiliated Hospital of Guangzhou Medical University, No.250 Changgangdong Road, Guangzhou 510260, China
Yingchun Zhou: School of Traditional Chinese Medicine, Department of Traditional Chinese Medicine, Nanfang Hospital (ZengCheng Branch), Southern Medical University, Guangzhou 510515, China; Correspondence to: Department of Traditional Chinese Medicine, the Second Affiliated Hospital of Guangzhou Medical University, No. 250 Changgangdong Road, Guangzhou 510260, China.
Weiwei Wu: Department of Rehabilitation, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China; Correspondence to: Department of Traditional Chinese Medicine, the Second Affiliated Hospital of Guangzhou Medical University, No. 250 Changgangdong Road, Guangzhou 510260, China.
Bin Liu: Department of Traditional Chinese Medicine, Guangzhou Institute of Cardiovascular Disease, State Key Laboratory of Respiratory Disease, Institute of Integration of Traditional and Western Medicine of Guangzhou Medical University, The Second Affiliated Hospital of Guangzhou Medical University, No.250 Changgangdong Road, Guangzhou 510260, China; Correspondence to: Department of Traditional Chinese Medicine, the Second Affiliated Hospital of Guangzhou Medical University, No. 250 Changgangdong Road, Guangzhou 510260, China.

Journal volume & issue: Vol. 177
p. 117012

Abstract

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Myocardial fibrosis is a pathological, physiological change that results from alterations, such as inflammation and metabolic dysfunction, after myocardial infarction (MI). Excessive fibrosis can cause cardiac dysfunction, ventricular remodeling, and heart failure. Caffeic acid (CA), a natural polyphenolic acid in various foods, has cardioprotective effects. This study aimed to explore whether CA exerts a cardioprotective effect to inhibit myocardial fibrosis post-MI and elucidate the underlying mechanisms. Histological observations indicated that CA ameliorated ventricular remodeling induced by left anterior descending coronary artery ligation in MI mice and partially restored cardiac function. CA selectively targeted transforming growth factor-β receptor 1 (TGFBR1) and inhibited TGFBR1-Smad2/3 signaling, reducing collagen deposition in the infarcted area of MI mice hearts. Furthermore, cell counting (CCK-8) assay, 5-ethynyl-2′-deoxyuridine assay, and western blotting revealed that CA dose-dependently decreased the proliferation, collagen synthesis, and activation of the TGFBR1-Smad2/3 pathway in primary cardiac fibroblasts (CFs) stimulated by TGF-β1 in vitro. Notably, TGFBR1 overexpression in CFs partially counteracted the inhibitory effects of CA. These findings suggest that CA effectively mitigates myocardial fibrosis and enhances cardiac function following MI and that this effect may be associated with the direct targeting of TGFBR1 by CA.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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