Nature Communications (Jul 2020)
Targeting QKI-7 in vivo restores endothelial cell function in diabetes
- Chunbo Yang,
- Magdalini Eleftheriadou,
- Sophia Kelaini,
- Thomas Morrison,
- Marta Vilà González,
- Rachel Caines,
- Nicola Edwards,
- Andrew Yacoub,
- Kevin Edgar,
- Arya Moez,
- Aleksandar Ivetic,
- Anna Zampetaki,
- Lingfang Zeng,
- Fiona L. Wilkinson,
- Noemi Lois,
- Alan W. Stitt,
- David J. Grieve,
- Andriana Margariti
Affiliations
- Chunbo Yang
- The Wellcome-Wolfson Institute of Experimental Medicine
- Magdalini Eleftheriadou
- The Wellcome-Wolfson Institute of Experimental Medicine
- Sophia Kelaini
- The Wellcome-Wolfson Institute of Experimental Medicine
- Thomas Morrison
- The Wellcome-Wolfson Institute of Experimental Medicine
- Marta Vilà González
- The Wellcome-Wolfson Institute of Experimental Medicine
- Rachel Caines
- The Wellcome-Wolfson Institute of Experimental Medicine
- Nicola Edwards
- Centre for Bioscience in the Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University
- Andrew Yacoub
- The Wellcome-Wolfson Institute of Experimental Medicine
- Kevin Edgar
- The Wellcome-Wolfson Institute of Experimental Medicine
- Arya Moez
- The Wellcome-Wolfson Institute of Experimental Medicine
- Aleksandar Ivetic
- School of Cardiovascular Medicine and Sciences, BHF Centre of Research Excellence, King’s College London, The James Black Centre
- Anna Zampetaki
- School of Cardiovascular Medicine and Sciences, BHF Centre of Research Excellence, King’s College London, The James Black Centre
- Lingfang Zeng
- School of Cardiovascular Medicine and Sciences, BHF Centre of Research Excellence, King’s College London, The James Black Centre
- Fiona L. Wilkinson
- Centre for Bioscience in the Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University
- Noemi Lois
- The Wellcome-Wolfson Institute of Experimental Medicine
- Alan W. Stitt
- The Wellcome-Wolfson Institute of Experimental Medicine
- David J. Grieve
- The Wellcome-Wolfson Institute of Experimental Medicine
- Andriana Margariti
- The Wellcome-Wolfson Institute of Experimental Medicine
- DOI
- https://doi.org/10.1038/s41467-020-17468-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Vascular endothelial cell (EC) dysfunction contributes to the occurrence of diabetic complications. Here the authors report that in diabetic conditions, upregulation of the RNA binding protein QKI-7 in ECs due to the imbalance of RNA splicing factors CUG-BP and hnRNPM contributes to EC dysfunction, and that in vivo QKI-7 silencing improves blood flow recovery in diabetic mice with limb ischemia.
