Nature Communications (Sep 2022)
Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity
- Xiwen Xiong,
- Chenyan Yang,
- Wei-Qi He,
- Jiahui Yu,
- Yue Xin,
- Xinge Zhang,
- Rong Huang,
- Honghui Ma,
- Shaofang Xu,
- Zun Li,
- Jie Ma,
- Lin Xu,
- Qunyi Wang,
- Kaiqun Ren,
- Xiaoli S. Wu,
- Christopher R. Vakoc,
- Jiateng Zhong,
- Genshen Zhong,
- Xiaofei Zhu,
- Yu Song,
- Hai-Bin Ruan,
- Qingzhi Wang
Affiliations
- Xiwen Xiong
- School of Forensic Medicine, Xinxiang Medical University
- Chenyan Yang
- School of Forensic Medicine, Xinxiang Medical University
- Wei-Qi He
- Jiangsu Key Laboratory of Neuropsychiatric Diseases and Cambridge-Suda (CAM-SU) Genomic Resource Center, Suzhou Medical College of Soochow University
- Jiahui Yu
- School of Forensic Medicine, Xinxiang Medical University
- Yue Xin
- School of Forensic Medicine, Xinxiang Medical University
- Xinge Zhang
- School of Forensic Medicine, Xinxiang Medical University
- Rong Huang
- School of Forensic Medicine, Xinxiang Medical University
- Honghui Ma
- School of Forensic Medicine, Xinxiang Medical University
- Shaofang Xu
- Jiangsu Key Laboratory of Neuropsychiatric Diseases and Cambridge-Suda (CAM-SU) Genomic Resource Center, Suzhou Medical College of Soochow University
- Zun Li
- School of Forensic Medicine, Xinxiang Medical University
- Jie Ma
- School of Basic Medical Sciences, Xinxiang Medical University
- Lin Xu
- School of Laboratory Medicine, Xinxiang Medical University
- Qunyi Wang
- The Third Affiliated Hospital of Xinxiang Medical University
- Kaiqun Ren
- Hunan Normal University School of Medicine
- Xiaoli S. Wu
- Cold Spring Harbor Laboratory
- Christopher R. Vakoc
- Cold Spring Harbor Laboratory
- Jiateng Zhong
- School of Basic Medical Sciences, Xinxiang Medical University
- Genshen Zhong
- School of Laboratory Medicine, Xinxiang Medical University
- Xiaofei Zhu
- School of Laboratory Medicine, Xinxiang Medical University
- Yu Song
- School of Pharmacy, Xinxiang Medical University
- Hai-Bin Ruan
- Department of Integrative Biology and Physiology, University of Minnesota Medical School
- Qingzhi Wang
- School of Forensic Medicine, Xinxiang Medical University
- DOI
- https://doi.org/10.1038/s41467-022-32846-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Host defense against helminth infection is mediated by mucosal type 2 immunity. Using gain- and loss-of-function mouse models, and mouse intestinal organoids, Xiong et al. show that SIRT6 modulates tuft and goblet cell expansion in intestinal epithelium by activating STAT6 to maintain type 2 mucosal immunity in response to helminth infection.
