PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression

Xianchun Lan; Song Ding; Tianzhe Zhang; Ying Yi; Conghui Li; Wenwen Jin; Jian Chen; Kaiwei Liang; Hengbin Wang; Wei Jiang

doi:10.1038/s41467-022-32295-z

Nature Communications (Aug 2022)

PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression

Xianchun Lan,
Song Ding,
Tianzhe Zhang,
Ying Yi,
Conghui Li,
Wenwen Jin,
Jian Chen,
Kaiwei Liang,
Hengbin Wang,
Wei Jiang

Affiliations

Xianchun Lan: Department of Biological Repositories, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, RNA Institute, Zhongnan Hospital of Wuhan University, Wuhan University
Song Ding: Department of Biological Repositories, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, RNA Institute, Zhongnan Hospital of Wuhan University, Wuhan University
Tianzhe Zhang: Department of Biological Repositories, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, RNA Institute, Zhongnan Hospital of Wuhan University, Wuhan University
Ying Yi: Department of Biological Repositories, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, RNA Institute, Zhongnan Hospital of Wuhan University, Wuhan University
Conghui Li: Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University
Wenwen Jin: Department of Biological Repositories, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, RNA Institute, Zhongnan Hospital of Wuhan University, Wuhan University
Jian Chen: Chinese Institute for Brain Research (Beijing), Research Unit of Medical Neurobiology, Chinese Academy of Medical Sciences
Kaiwei Liang: Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University
Hengbin Wang: Department of Internal Medicine, Division of Hematology, Oncology, and Palliative Care, Massey Cancer Center, Virginia Commonwealth University
Wei Jiang: Department of Biological Repositories, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, RNA Institute, Zhongnan Hospital of Wuhan University, Wuhan University

DOI: https://doi.org/10.1038/s41467-022-32295-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Variant Polycomb complexes can have tissue-specific roles during development. Here they show that PCGF6 controls lineage-specification in human PSCs by promoting neuroectoderm differentiation and repressing mesendoderm differentiation via distinct downstream targets.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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