First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain

T. Pelaez; M.C. Monteiro; R. Garcia-Rubio; E. Bouza; A. Gomez-Lopez; E. Mellado

doi:10.1016/j.nmni.2015.04.005

New Microbes and New Infections (Jul 2015)

First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain

T. Pelaez,
M.C. Monteiro,
R. Garcia-Rubio,
E. Bouza,
A. Gomez-Lopez,
E. Mellado

Affiliations

T. Pelaez: Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón and Department of Medicine, Faculty of Medicine, Universidad Complutense, Madrid, Spain
M.C. Monteiro: Mycology Reference Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain
R. Garcia-Rubio: Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón and Department of Medicine, Faculty of Medicine, Universidad Complutense, Madrid, Spain
E. Bouza: Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón and Department of Medicine, Faculty of Medicine, Universidad Complutense, Madrid, Spain
A. Gomez-Lopez: Mycology Reference Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain
E. Mellado: Mycology Reference Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain

DOI: https://doi.org/10.1016/j.nmni.2015.04.005
Journal volume & issue: Vol. 6, no. C
pp. 33 – 34

Abstract

Read online

We report the first isolation of a voriconazole-resistant Aspergillus fumigatus strain harbouring the azole resistance mechanism TR46/Y121F/T289A, recovered from an azole-naive patient in Spain with chronic obstructive pulmonary disease. This new finding in Spain suggests the spread of this resistance mechanism and reinforces the need for antifungal susceptibility surveillance.

Published in New Microbes and New Infections

ISSN: 2052-2975 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: http://www.journals.elsevier.com/new-microbes-and-new-infections/

About the journal

Abstract

Keywords