Frontiers in Molecular Biosciences (Sep 2021)
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer
- Javad Sharifi-Rad,
- Cristina Quispe,
- Zhazira Mukazhanova,
- Ewa Knut,
- Aknur Turgumbayeva,
- Aknur Turgumbayeva,
- Aliya Kipchakbayeva,
- Gulnaz Seitimova,
- Mohamad Fawzi Mahomoodally,
- Devina Lobine,
- Aaron Koay,
- Jinfan Wang,
- Helen Sheridan,
- Gerardo Leyva-Gómez,
- María L. Del Prado-Audelo,
- Hernán Cortes,
- Antonio Rescigno,
- Paolo Zucca,
- Oksana Sytar,
- Oksana Sytar,
- Muhammad Imran,
- Célia F. Rodrigues,
- Natália Cruz-Martins,
- Natália Cruz-Martins,
- Natália Cruz-Martins,
- Halina Ekiert,
- Manoj Kumar,
- Ahmad Faizal Abdull Razis,
- Ahmad Faizal Abdull Razis,
- Usman Sunusi,
- Usman Sunusi,
- Ramla Muhammad Kamal,
- Ramla Muhammad Kamal,
- Agnieszka Szopa
Affiliations
- Javad Sharifi-Rad
- Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- Cristina Quispe
- Facultad de Ciencias de la Salud, Universidad Arturo Prat, Iquique, Chile
- Zhazira Mukazhanova
- Department of Natural Sciences and Technologies, Sarsen Amanzholov East Kazakhstan State University, Ust-Kamenogorsk, Kazakhstan
- Ewa Knut
- Chair and Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland
- Aknur Turgumbayeva
- Asfendiyarov Kazakh National Medical University, School Pharmacy, Almaty, Kazakhstan
- Aknur Turgumbayeva
- Al-Farabi Kazakh National University, Higher School of Medicine, Almaty, Kazakhstan
- Aliya Kipchakbayeva
- Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
- Gulnaz Seitimova
- Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
- Mohamad Fawzi Mahomoodally
- Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit, Mauritius
- Devina Lobine
- Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit, Mauritius
- Aaron Koay
- Trinity College Dublin, NatPro (Natural Products Research Centre), School of Pharmacy and Pharmaceutical Science, Dublin, Ireland
- Jinfan Wang
- Trinity College Dublin, NatPro (Natural Products Research Centre), School of Pharmacy and Pharmaceutical Science, Dublin, Ireland
- Helen Sheridan
- Trinity College Dublin, NatPro (Natural Products Research Centre), School of Pharmacy and Pharmaceutical Science, Dublin, Ireland
- Gerardo Leyva-Gómez
- 0Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico City, Mexico
- María L. Del Prado-Audelo
- 0Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico City, Mexico
- Hernán Cortes
- 1Laboratorio de Medicina Genómica, Departamento de Genética, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, Mexico City, Mexico
- Antonio Rescigno
- 2Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, Cagliari, Italy
- Paolo Zucca
- 2Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, Cagliari, Italy
- Oksana Sytar
- 3Department of Plant Biology, Institute of Biology, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
- Oksana Sytar
- 4Department of Plant Physiology, Slovak University of Agriculture, Nitra, Slovakia
- Muhammad Imran
- 5University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan
- Célia F. Rodrigues
- 6Laboratory for Process Engineering, Environment, Biotechnology and Energy—Department of Chemical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal
- Natália Cruz-Martins
- 7Faculty of Medicine, University of Porto, Porto, Portugal
- Natália Cruz-Martins
- 8Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal
- Natália Cruz-Martins
- 9Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal
- Halina Ekiert
- Chair and Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland
- Manoj Kumar
- 0Chemical and Biochemical Processing Division, ICAR – Central Institute for Research on Cotton Technology, Mumbai, India
- Ahmad Faizal Abdull Razis
- 1Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia
- Ahmad Faizal Abdull Razis
- 2Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
- Usman Sunusi
- 2Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
- Usman Sunusi
- 3Department of Biochemistry, Bayero University Kano, Kano, Nigeria
- Ramla Muhammad Kamal
- 2Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
- Ramla Muhammad Kamal
- 4Department of Pharmacology, Federal University Dutse, Dutse, Nigeria
- Agnieszka Szopa
- Chair and Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland
- DOI
- https://doi.org/10.3389/fmolb.2021.649395
- Journal volume & issue
-
Vol. 8
Abstract
Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.
Keywords
