The role of calcium metabolism dysregulation in the pathogenesis of cardiovascular diseases

Abstract

The review presents data on the causes of dysregulation of calcium metabolism and its association with the main elements of the cardiovascular continuum. Particular attention was paid to its role in the regulation of endothelial function, systemic inflammation, myocardial contractility, lipid and carbohydrate metabolism, the disruption of which determines the initiation and progression of diseases such as essential hypertension and chronic heart failure. We also systematized data on the role and methods of calcium dysmetabolism correcting in the prevention and treatment of these pathologies.

Keywords

• calcium
• cardiovascular disease
• arterial hypertension
• chronic heart failure
• pathogenesis