Single dose of chimeric dengue-2/Zika vaccine candidate protects mice and non-human primates against Zika virus

Whitney R. Baldwin; Holli A. Giebler; Janae L. Stovall; Ginger Young; Kelly J. Bohning; Hansi J. Dean; Jill A. Livengood; Claire Y.-H. Huang

doi:10.1038/s41467-021-27578-w

Nature Communications (Dec 2021)

Single dose of chimeric dengue-2/Zika vaccine candidate protects mice and non-human primates against Zika virus

Whitney R. Baldwin,
Holli A. Giebler,
Janae L. Stovall,
Ginger Young,
Kelly J. Bohning,
Hansi J. Dean,
Jill A. Livengood,
Claire Y.-H. Huang

Affiliations

Whitney R. Baldwin: Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention
Holli A. Giebler: Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention
Janae L. Stovall: Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention
Ginger Young: Takeda Vaccines Inc.
Kelly J. Bohning: Takeda Vaccines Inc.
Hansi J. Dean: Takeda Vaccines Inc.
Jill A. Livengood: Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention
Claire Y.-H. Huang: Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention

DOI: https://doi.org/10.1038/s41467-021-27578-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Here the authors generate a live-attenuated Zika vaccine based on a clinically proven dengue virus serotype-2 vaccine backbone and show that one dose protects mice and non-human primates from Zika virus infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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