Nature Communications (Sep 2021)
Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis
- David M. Zhang,
- Rachita Navara,
- Tiankai Yin,
- Jeffrey Szymanski,
- Uri Goldsztejn,
- Camryn Kenkel,
- Adam Lang,
- Cedric Mpoy,
- Catherine E. Lipovsky,
- Yun Qiao,
- Stephanie Hicks,
- Gang Li,
- Kaitlin M. S. Moore,
- Carmen Bergom,
- Buck E. Rogers,
- Clifford G. Robinson,
- Phillip S. Cuculich,
- Julie K. Schwarz,
- Stacey L. Rentschler
Affiliations
- David M. Zhang
- Center for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine
- Rachita Navara
- Center for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine
- Tiankai Yin
- Department of Medicine, Cardiovascular Division, Washington University in St. Louis, School of Medicine
- Jeffrey Szymanski
- Department of Radiation Oncology, Washington University in St. Louis, School of Medicine
- Uri Goldsztejn
- Department of Medicine, Cardiovascular Division, Washington University in St. Louis, School of Medicine
- Camryn Kenkel
- Department of Medicine, Cardiovascular Division, Washington University in St. Louis, School of Medicine
- Adam Lang
- Department of Pathology, Washington University in St. Louis, School of Medicine
- Cedric Mpoy
- Department of Radiation Oncology, Washington University in St. Louis, School of Medicine
- Catherine E. Lipovsky
- Department of Medicine, Cardiovascular Division, Washington University in St. Louis, School of Medicine
- Yun Qiao
- Department of Medicine, Cardiovascular Division, Washington University in St. Louis, School of Medicine
- Stephanie Hicks
- Department of Medicine, Cardiovascular Division, Washington University in St. Louis, School of Medicine
- Gang Li
- Department of Medicine, Cardiovascular Division, Washington University in St. Louis, School of Medicine
- Kaitlin M. S. Moore
- Center for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine
- Carmen Bergom
- Center for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine
- Buck E. Rogers
- Department of Radiation Oncology, Washington University in St. Louis, School of Medicine
- Clifford G. Robinson
- Center for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine
- Phillip S. Cuculich
- Center for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine
- Julie K. Schwarz
- Center for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine
- Stacey L. Rentschler
- Center for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-25730-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Noninvasive cardiac radiotherapy may effectively manage ventricular tachycardia in refractory patients, but its radiobiologic mechanisms of action are unclear. Here, the authors show that photon radiation durably and favourably reprograms cardiac conduction in the absence of transmural fibrosis suggesting this could be the mechanism through which cardiac radiotherapy to modulates arrhythmia susceptibility.
