Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7

Di Wu; Di Wu; Yinglu Li; Kathy S. Zhu; Haiying Wang; Haiying Wang; Wei-Guo Zhu

doi:10.3389/fendo.2018.00652

Frontiers in Endocrinology (Nov 2018)

Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7

Di Wu,
Di Wu,
Yinglu Li,
Kathy S. Zhu,
Haiying Wang,
Haiying Wang,
Wei-Guo Zhu

Affiliations

Di Wu: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
Di Wu: School of Basic Medical Sciences, Institute of Systems Biomedicine, Peking University Health Science Center, Beijing, China
Yinglu Li: Department of Biochemistry and Molecular Biology, Shenzhen University Health Science Center, Shenzhen, China
Kathy S. Zhu: Peking University Health Science Center, School of Public Health, Beijing, China
Haiying Wang: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
Haiying Wang: Department of Biochemistry and Molecular Biology, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
Wei-Guo Zhu: Department of Biochemistry and Molecular Biology, Shenzhen University Health Science Center, Shenzhen, China

DOI: https://doi.org/10.3389/fendo.2018.00652
Journal volume & issue: Vol. 9

Abstract

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SIRT7 is one of seven mammalian sirtuins that functions as an NAD+-dependent histone/protein deacetylase. SIRT7 is the least well-known member of the sirtuin family, but recent efforts have identified its involvement in various cellular processes, such as ribosome biogenesis, gene expression, cellular metabolism and cancer. Here we provide an update on the functions and mechanisms of SIRT7 in cellular regulation and disease.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

About the journal

Abstract

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