Nature Communications (Jul 2018)
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function
- Annah B. Wyss,
- Tamar Sofer,
- Mi Kyeong Lee,
- Natalie Terzikhan,
- Jennifer N. Nguyen,
- Lies Lahousse,
- Jeanne C. Latourelle,
- Albert Vernon Smith,
- Traci M. Bartz,
- Mary F. Feitosa,
- Wei Gao,
- Tarunveer S. Ahluwalia,
- Wenbo Tang,
- Christopher Oldmeadow,
- Qing Duan,
- Kim de Jong,
- Mary K. Wojczynski,
- Xin-Qun Wang,
- Raymond Noordam,
- Fernando Pires Hartwig,
- Victoria E. Jackson,
- Tianyuan Wang,
- Ma’en Obeidat,
- Brian D. Hobbs,
- Tianxiao Huan,
- Hongsheng Gui,
- Margaret M. Parker,
- Donglei Hu,
- Lauren S. Mogil,
- Gleb Kichaev,
- Jianping Jin,
- Mariaelisa Graff,
- Tamara B. Harris,
- Ravi Kalhan,
- Susan R. Heckbert,
- Lavinia Paternoster,
- Kristin M. Burkart,
- Yongmei Liu,
- Elizabeth G. Holliday,
- James G. Wilson,
- Judith M. Vonk,
- Jason L. Sanders,
- R. Graham Barr,
- Renée de Mutsert,
- Ana Maria Baptista Menezes,
- Hieab H. H. Adams,
- Maarten van den Berge,
- Roby Joehanes,
- Albert M. Levin,
- Jennifer Liberto,
- Lenore J. Launer,
- Alanna C. Morrison,
- Colleen M. Sitlani,
- Juan C. Celedón,
- Stephen B. Kritchevsky,
- Rodney J. Scott,
- Kaare Christensen,
- Jerome I. Rotter,
- Tobias N. Bonten,
- Fernando César Wehrmeister,
- Yohan Bossé,
- Shujie Xiao,
- Sam Oh,
- Nora Franceschini,
- Jennifer A. Brody,
- Robert C. Kaplan,
- Kurt Lohman,
- Mark McEvoy,
- Michael A. Province,
- Frits R. Rosendaal,
- Kent D. Taylor,
- David C. Nickle,
- L. Keoki Williams,
- Esteban G. Burchard,
- Heather E. Wheeler,
- Don D. Sin,
- Vilmundur Gudnason,
- Kari E. North,
- Myriam Fornage,
- Bruce M. Psaty,
- Richard H. Myers,
- George O’Connor,
- Torben Hansen,
- Cathy C. Laurie,
- Patricia A. Cassano,
- Joohon Sung,
- Woo Jin Kim,
- John R. Attia,
- Leslie Lange,
- H. Marike Boezen,
- Bharat Thyagarajan,
- Stephen S. Rich,
- Dennis O. Mook-Kanamori,
- Bernardo Lessa Horta,
- André G. Uitterlinden,
- Hae Kyung Im,
- Michael H. Cho,
- Guy G. Brusselle,
- Sina A. Gharib,
- Josée Dupuis,
- Ani Manichaikul,
- Stephanie J. London
Affiliations
- Annah B. Wyss
- Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services
- Tamar Sofer
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Mi Kyeong Lee
- Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services
- Natalie Terzikhan
- Department of Respiratory Medicine, Ghent University Hospital
- Jennifer N. Nguyen
- Center for Public Health Genomics, University of Virginia
- Lies Lahousse
- Department of Epidemiology, Erasmus University Medical Center
- Jeanne C. Latourelle
- Department of Neurology, Boston University School of Medicine
- Albert Vernon Smith
- Icelandic Heart Association
- Traci M. Bartz
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Mary F. Feitosa
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Wei Gao
- Department of Biostatistics, Boston University School of Public Health
- Tarunveer S. Ahluwalia
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Metabolic Genetics Section, Faculty of Health and Medical Sciences, University of Copenhagen
- Wenbo Tang
- Division of Nutritional Sciences, Cornell University
- Christopher Oldmeadow
- Hunter Medical Research Institute and Faculty of Health, University of Newcastle
- Qing Duan
- Department of Genetics, University of North Carolina
- Kim de Jong
- Department of Epidemiologie, University of Groningen, University Medical Center Groningen
- Mary K. Wojczynski
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Xin-Qun Wang
- Division of Biostatistics, Department of Public Health Sciences, University of Virginia
- Raymond Noordam
- Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center
- Fernando Pires Hartwig
- Postgraduate Program in Epidemiology, Federal University of Pelotas
- Victoria E. Jackson
- Department of Health Sciences, University of Leicester
- Tianyuan Wang
- Integrative Bioinformatics Support Group National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services
- Ma’en Obeidat
- The University of British Columbia Center for Heart Lung Innovation, St Paul’s Hospital
- Brian D. Hobbs
- Channing Division of Network Medicine, Brigham and Women’s Hospital
- Tianxiao Huan
- The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute
- Hongsheng Gui
- Center for Health Policy and Health Services Research, Henry Ford Health System
- Margaret M. Parker
- Channing Division of Network Medicine, Brigham and Women’s Hospital
- Donglei Hu
- School of Medicine, University of California San Francisco
- Lauren S. Mogil
- Department of Biology, Loyola University Chicago
- Gleb Kichaev
- University of California Los Angeles
- Jianping Jin
- Westat
- Mariaelisa Graff
- Department of Epidemiology, University of North Carolina
- Tamara B. Harris
- Department of Health and Human Services, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Ravi Kalhan
- Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine
- Susan R. Heckbert
- Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington
- Lavinia Paternoster
- Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol
- Kristin M. Burkart
- Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University
- Yongmei Liu
- Wake Forest School of Medicine
- Elizabeth G. Holliday
- Hunter Medical Research Institute and Faculty of Health, University of Newcastle
- James G. Wilson
- Department of Physiology and Biophysics, University of Mississippi Medical Center
- Judith M. Vonk
- Department of Epidemiologie, University of Groningen, University Medical Center Groningen
- Jason L. Sanders
- Department of Medicine, Massachusetts General Hospital
- R. Graham Barr
- Department of Medicine, College of Physicians and Surgeons, Columbia University
- Renée de Mutsert
- Department of Clinical Epidemiology, Leiden University Medical Center
- Ana Maria Baptista Menezes
- Postgraduate Program in Epidemiology, Federal University of Pelotas
- Hieab H. H. Adams
- Department of Epidemiology, Erasmus University Medical Center
- Maarten van den Berge
- Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen
- Roby Joehanes
- Hebrew SeniorLife, Harvard University
- Albert M. Levin
- Department of Public Health Sciences, Henry Ford Health System
- Jennifer Liberto
- School of Medicine, University of California San Francisco
- Lenore J. Launer
- Department of Health and Human Services, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Alanna C. Morrison
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Colleen M. Sitlani
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Juan C. Celedón
- Division of Pulmonary Medicine, Allergy, and Immunology, Department of Pediatrics, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh
- Stephen B. Kritchevsky
- Sticht Center for Healthy Aging and Alzheimer’s Prevention, Wake Forest School of Medicine
- Rodney J. Scott
- Hunter Medical Research Institute and Faculty of Health, University of Newcastle
- Kaare Christensen
- Department of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark
- Jerome I. Rotter
- Department of Pediatrics, Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center
- Tobias N. Bonten
- Department of Public Health and Primary Care, Leiden University Medical Center
- Fernando César Wehrmeister
- Postgraduate Program in Epidemiology, Federal University of Pelotas
- Yohan Bossé
- Department of Molecular Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University
- Shujie Xiao
- Center for Health Policy and Health Services Research, Henry Ford Health System
- Sam Oh
- School of Medicine, University of California San Francisco
- Nora Franceschini
- Department of Epidemiology, University of North Carolina
- Jennifer A. Brody
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Robert C. Kaplan
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine
- Kurt Lohman
- Wake Forest School of Medicine
- Mark McEvoy
- Hunter Medical Research Institute and Faculty of Health, University of Newcastle
- Michael A. Province
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Frits R. Rosendaal
- Department of Clinical Epidemiology, Leiden University Medical Center
- Kent D. Taylor
- Department of Pediatrics, Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center
- David C. Nickle
- Merck Research Laboratories, GpGx, Merck & Co., Inc.
- L. Keoki Williams
- Center for Health Policy and Health Services Research, Henry Ford Health System
- Esteban G. Burchard
- School of Medicine, University of California San Francisco
- Heather E. Wheeler
- Department of Biology, Loyola University Chicago
- Don D. Sin
- The University of British Columbia Center for Heart Lung Innovation, St Paul’s Hospital
- Vilmundur Gudnason
- Icelandic Heart Association
- Kari E. North
- Department of Epidemiology, University of North Carolina
- Myriam Fornage
- Brown Foundation Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Richard H. Myers
- Department of Neurology, Boston University School of Medicine
- George O’Connor
- National Heart, Lung, and Blood Institute’s Framingham Heart Study
- Torben Hansen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Metabolic Genetics Section, Faculty of Health and Medical Sciences, University of Copenhagen
- Cathy C. Laurie
- Department of Biostatistics, University of Washington
- Patricia A. Cassano
- Division of Nutritional Sciences, Cornell University
- Joohon Sung
- Department of Health Science, School of Public Health, Seoul National University
- Woo Jin Kim
- Department of Internal Medicine and Environmental Health Center, Kangwon National University
- John R. Attia
- Hunter Medical Research Institute and Faculty of Health, University of Newcastle
- Leslie Lange
- University of Colorado Denver
- H. Marike Boezen
- Department of Epidemiologie, University of Groningen, University Medical Center Groningen
- Bharat Thyagarajan
- Department of Laboratory Medicine and Pathology, University of Minnesota
- Stephen S. Rich
- Center for Public Health Genomics, University of Virginia
- Dennis O. Mook-Kanamori
- Department of Clinical Epidemiology, Leiden University Medical Center
- Bernardo Lessa Horta
- Postgraduate Program in Epidemiology, Federal University of Pelotas
- André G. Uitterlinden
- Department of Internal Medicine, Erasmus University Medical Center
- Hae Kyung Im
- Section of Genetic Medicine, The University of Chicago
- Michael H. Cho
- Channing Division of Network Medicine, Brigham and Women’s Hospital
- Guy G. Brusselle
- Department of Respiratory Medicine, Ghent University Hospital
- Sina A. Gharib
- Department of Medicine, Computational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, University of Washington
- Josée Dupuis
- Department of Biostatistics, Boston University School of Public Health
- Ani Manichaikul
- Center for Public Health Genomics, University of Virginia
- Stephanie J. London
- Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services
- DOI
- https://doi.org/10.1038/s41467-018-05369-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Pulmonary function is influenced by environmental factors, lifestyle, and genetics. Here, in a multiethnic GWAS meta-analysis for pulmonary function traits, the authors identify over 50 additional genetic loci, a subset of which are specific for European, African, Asian, or Hispanic/Latino ancestry.
