Nature Communications (Aug 2018)
A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
- Nigel Turner,
- Xin Ying Lim,
- Hamish D. Toop,
- Brenna Osborne,
- Amanda E. Brandon,
- Elysha N. Taylor,
- Corrine E. Fiveash,
- Hemna Govindaraju,
- Jonathan D. Teo,
- Holly P. McEwen,
- Timothy A. Couttas,
- Stephen M. Butler,
- Abhirup Das,
- Greg M. Kowalski,
- Clinton R. Bruce,
- Kyle L. Hoehn,
- Thomas Fath,
- Carsten Schmitz-Peiffer,
- Gregory J. Cooney,
- Magdalene K. Montgomery,
- Jonathan C. Morris,
- Anthony S. Don
Affiliations
- Nigel Turner
- School of Medical Sciences, UNSW Sydney
- Xin Ying Lim
- Prince of Wales Clinical School, Faculty of Medicine, UNSW Sydney
- Hamish D. Toop
- School of Chemistry, UNSW Sydney
- Brenna Osborne
- School of Medical Sciences, UNSW Sydney
- Amanda E. Brandon
- Sydney Medical School, Charles Perkins Centre, University of Sydney
- Elysha N. Taylor
- School of Chemistry, UNSW Sydney
- Corrine E. Fiveash
- School of Medical Sciences, UNSW Sydney
- Hemna Govindaraju
- School of Medical Sciences, UNSW Sydney
- Jonathan D. Teo
- Centenary Institute, The University of Sydney
- Holly P. McEwen
- Centenary Institute, The University of Sydney
- Timothy A. Couttas
- Centenary Institute, The University of Sydney
- Stephen M. Butler
- School of Chemistry, UNSW Sydney
- Abhirup Das
- School of Medical Sciences, UNSW Sydney
- Greg M. Kowalski
- Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University
- Clinton R. Bruce
- Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University
- Kyle L. Hoehn
- School of Biotechnology and Biomolecular Sciences, UNSW Sydney
- Thomas Fath
- School of Medical Sciences, UNSW Sydney
- Carsten Schmitz-Peiffer
- Garvan Institute of Medical Research
- Gregory J. Cooney
- Sydney Medical School, Charles Perkins Centre, University of Sydney
- Magdalene K. Montgomery
- School of Medical Sciences, UNSW Sydney
- Jonathan C. Morris
- School of Chemistry, UNSW Sydney
- Anthony S. Don
- Centenary Institute, The University of Sydney
- DOI
- https://doi.org/10.1038/s41467-018-05613-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Ceramides are signalling molecules that regulate several physiological functions including insulin sensitivity. Here the authors report a selective ceramide synthase 1 inhibitor that counteracts lipid accumulation within the muscle and adiposity by increasing fatty acid oxidation but without affecting insulin sensitivity in mice fed with an obesogenic diet.
