Nature Communications (Feb 2020)
Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance
- Rieke Martens,
- Marc Permanyer,
- Kathrin Werth,
- Kai Yu,
- Asolina Braun,
- Olga Halle,
- Stephan Halle,
- Gwendolyn E. Patzer,
- Berislav Bošnjak,
- Friedemann Kiefer,
- Anika Janssen,
- Michaela Friedrichsen,
- Jenny Poetzsch,
- Karan Kohli,
- Yvonne Lueder,
- Rodrigo Gutierrez Jauregui,
- Nadine Eckert,
- Tim Worbs,
- Melanie Galla,
- Reinhold Förster
Affiliations
- Rieke Martens
- Institute of Immunology, Hannover Medical School
- Marc Permanyer
- Institute of Immunology, Hannover Medical School
- Kathrin Werth
- Institute of Immunology, Hannover Medical School
- Kai Yu
- Institute of Immunology, Hannover Medical School
- Asolina Braun
- Institute of Immunology, Hannover Medical School
- Olga Halle
- Institute of Immunology, Hannover Medical School
- Stephan Halle
- Institute of Immunology, Hannover Medical School
- Gwendolyn E. Patzer
- Institute of Immunology, Hannover Medical School
- Berislav Bošnjak
- Institute of Immunology, Hannover Medical School
- Friedemann Kiefer
- Mammalian Cell Signaling Laboratory, Max Planck Institute for Molecular Biomedicine
- Anika Janssen
- Institute of Immunology, Hannover Medical School
- Michaela Friedrichsen
- Institute of Immunology, Hannover Medical School
- Jenny Poetzsch
- Institute of Immunology, Hannover Medical School
- Karan Kohli
- Institute of Immunology, Hannover Medical School
- Yvonne Lueder
- Institute of Immunology, Hannover Medical School
- Rodrigo Gutierrez Jauregui
- Institute of Immunology, Hannover Medical School
- Nadine Eckert
- Institute of Immunology, Hannover Medical School
- Tim Worbs
- Institute of Immunology, Hannover Medical School
- Melanie Galla
- Institute of Experimental Hematology, Hannover Medical School
- Reinhold Förster
- Institute of Immunology, Hannover Medical School
- DOI
- https://doi.org/10.1038/s41467-020-14921-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Immune cells mostly enter lymph nodes (LN) from blood circulation, but whether afferent lymphatics contributes to LN entry is unclear. Here, the authors show, using a photo-convertible reporter, that T cells in afferent lymphatics frequently enter LN and become arrested in the subcapsular sinus, with chemokines and integrins further guiding their migration in the LN.
