Fragment Binding to β‑Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening Approaches

• Frederik J. R. Rombouts,
• Richard Alexander,
• Erna Cleiren,
• Alex De Groot,
• Michel Carpentier,
• Joyce Dijkmans,
• Katleen Fierens,
• Stefan Masure,
• Diederik Moechars,
• Martina Palomino-Schätzlein,
• Antonio Pineda-Lucena,
• Andrés A. Trabanco,
• Daan Van Glabbeek,
• Ann Vos,
• Gary Tresadern

Affiliations

Frederik J. R. Rombouts

†Neuroscience Medicinal Chemistry, Janssen Research & Development, Beerse, Belgium

Richard Alexander

Discovery Sciences, Janssen Research & Development, Spring House, Pennsylvania, United States

Erna Cleiren

‡Discovery Sciences, Janssen Research & Development, Beerse, Belgium

Alex De Groot

‡Discovery Sciences, Janssen Research & Development, Beerse, Belgium

Michel Carpentier

‡Discovery Sciences, Janssen Research & Development, Beerse, Belgium

Joyce Dijkmans

‡Discovery Sciences, Janssen Research & Development, Beerse, Belgium

Katleen Fierens

‡Discovery Sciences, Janssen Research & Development, Beerse, Belgium

Stefan Masure

‡Discovery Sciences, Janssen Research & Development, Beerse, Belgium

Diederik Moechars

§Neuroscience Biology, Janssen Research & Development, Beerse, Belgium

Martina Palomino-Schätzlein

Structural Biochemistry Laboratory, Centro de Investigación Príncipe Felipe, Valencia, Spain

Antonio Pineda-Lucena

Structural Biochemistry Laboratory, Centro de Investigación Príncipe Felipe, Valencia, Spain

Andrés A. Trabanco

Neuroscience Medicinal Chemistry, Janssen Research & Development, Toledo, Spain

Daan Van Glabbeek

‡Discovery Sciences, Janssen Research & Development, Beerse, Belgium

Ann Vos

‡Discovery Sciences, Janssen Research & Development, Beerse, Belgium

Gary Tresadern

‡Discovery Sciences, Janssen Research & Development, Beerse, Belgium