Nature Communications (Sep 2018)

Plasmodium co-infection protects against chikungunya virus-induced pathologies

  • Teck-Hui Teo,
  • Fok-Moon Lum,
  • Khairunnisa Ghaffar,
  • Yi-Hao Chan,
  • Siti Naqiah Amrun,
  • Jeslin J. L. Tan,
  • Cheryl Y. P. Lee,
  • Tze-Kwang Chua,
  • Guillaume Carissimo,
  • Wendy W. L. Lee,
  • Carla Claser,
  • Ravisankar Rajarethinam,
  • Laurent Rénia,
  • Lisa F. P. Ng

DOI
https://doi.org/10.1038/s41467-018-06227-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Chikungunya virus (CHIKV) and Plasmodium co-infections have been reported in humans, but effects of the two pathogens on each other are unclear. Here, Teo et al. show in mice that Plasmodium infection affects CHIKV-specific T and B cell responses, leading to reduced joint inflammation.