Evaluating a novel behavioral paradigm for visual hallucinations in Dementia with Lewy bodies

Joseph R. Phillips; Elie Matar; Kaylena A. Ehgoetz Martens; Ahmed A. Moustafa; Glenda M. Halliday; Simon J.G. Lewis

Aging Brain (Jan 2021)

Evaluating a novel behavioral paradigm for visual hallucinations in Dementia with Lewy bodies

Joseph R. Phillips,
Elie Matar,
Kaylena A. Ehgoetz Martens,
Ahmed A. Moustafa,
Glenda M. Halliday,
Simon J.G. Lewis

Affiliations

Joseph R. Phillips: Faculty of Medicine and Health, Brain and Mind Centre and Central Clinical School, University of Sydney, Camperdown, Sydney, Australia; School of Psychology & Marcs Institute for Brain and Behaviour, Western Sydney University, Sydney, New South Wales, Australia
Elie Matar: Faculty of Medicine and Health, Brain and Mind Centre and Central Clinical School, University of Sydney, Camperdown, Sydney, Australia; Dementia and Movement Disorders Laboratory, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia
Kaylena A. Ehgoetz Martens: Faculty of Medicine and Health, Brain and Mind Centre and Central Clinical School, University of Sydney, Camperdown, Sydney, Australia; Department of Kinesiology, Faculty of Health, University of Waterloo, Waterloo, Ontario, Canada
Ahmed A. Moustafa: Faculty of Medicine and Health, Brain and Mind Centre and Central Clinical School, University of Sydney, Camperdown, Sydney, Australia; School of Psychology & Marcs Institute for Brain and Behaviour, Western Sydney University, Sydney, New South Wales, Australia
Glenda M. Halliday: Faculty of Medicine and Health, Brain and Mind Centre and Central Clinical School, University of Sydney, Camperdown, Sydney, Australia; Dementia and Movement Disorders Laboratory, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia
Simon J.G. Lewis: Faculty of Medicine and Health, Brain and Mind Centre and Central Clinical School, University of Sydney, Camperdown, Sydney, Australia; Corresponding author at: Parkinson’s Disease Research Clinic, L2 Brain and Mind Centre, 97 Church Street, Camperdown, Sydney, New South Wales, Australia.

Journal volume & issue: Vol. 1
p. 100011

Abstract

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The aim of this study was to evaluate the utility of the Bistable Percept Paradigm (BPP), a computerised behavioural task that has previously been utilised for the assessment of visual hallucinations in Parkinson’s Disease, in a Dementia with Lewy bodies (DLB) cohort. Dementia with Lewy bodies patients demonstrated poorer performance than healthy controls (HC) on the BPP with significantly more misperceptions and a greater failure to detect bistable percepts correctly compared to HC. Further, the number of misperceptions was also correlated with the severity of hallucinations. The findings from this study demonstrate that the BPP is a viable tool to measure misperceptions in DLB patients.

Published in Aging Brain

ISSN: 2589-9589 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/aging-brain

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Abstract

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