Nature Communications (Jan 2021)
Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis
- Amit Rai,
- Hideki Hirakawa,
- Ryo Nakabayashi,
- Shinji Kikuchi,
- Koki Hayashi,
- Megha Rai,
- Hiroshi Tsugawa,
- Taiki Nakaya,
- Tetsuya Mori,
- Hideki Nagasaki,
- Runa Fukushi,
- Yoko Kusuya,
- Hiroki Takahashi,
- Hiroshi Uchiyama,
- Atsushi Toyoda,
- Shoko Hikosaka,
- Eiji Goto,
- Kazuki Saito,
- Mami Yamazaki
Affiliations
- Amit Rai
- Graduate School of Pharmaceutical Sciences, Chiba University
- Hideki Hirakawa
- Kazusa DNA Research Institute
- Ryo Nakabayashi
- RIKEN Center for Sustainable Resource Science
- Shinji Kikuchi
- Plant Molecular Science Center, Chiba University
- Koki Hayashi
- Graduate School of Pharmaceutical Sciences, Chiba University
- Megha Rai
- Graduate School of Pharmaceutical Sciences, Chiba University
- Hiroshi Tsugawa
- RIKEN Center for Sustainable Resource Science
- Taiki Nakaya
- Graduate School of Pharmaceutical Sciences, Chiba University
- Tetsuya Mori
- RIKEN Center for Sustainable Resource Science
- Hideki Nagasaki
- Kazusa DNA Research Institute
- Runa Fukushi
- Graduate School of Horticulture, Chiba University
- Yoko Kusuya
- Medical Mycology Research Center, Chiba University
- Hiroki Takahashi
- Plant Molecular Science Center, Chiba University
- Hiroshi Uchiyama
- College of Bioresource Sciences, Nihon University
- Atsushi Toyoda
- Advanced Genomics Center, National Institute of Genetics
- Shoko Hikosaka
- Plant Molecular Science Center, Chiba University
- Eiji Goto
- Plant Molecular Science Center, Chiba University
- Kazuki Saito
- Graduate School of Pharmaceutical Sciences, Chiba University
- Mami Yamazaki
- Graduate School of Pharmaceutical Sciences, Chiba University
- DOI
- https://doi.org/10.1038/s41467-020-20508-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Ophiorrhiza pumila is a medicinal plant that can produce the anti-cancer monoterpene indole alkaloid (MIA) camptothecin. Here, the authors report its genome assembly and propose a working model for MIA evolution and biosynthesis through comparative genomics, synteny, and metabolic gene cluster analyses.
