Bisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in Caenorhabditis elegans

Yisrael Rappaport; Hanna Achache; Roni Falk; Omer Murik; Oren Ram; Yonatan B. Tzur

doi:10.1038/s41467-021-24815-0

Nature Communications (Aug 2021)

Bisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in Caenorhabditis elegans

Yisrael Rappaport,
Hanna Achache,
Roni Falk,
Omer Murik,
Oren Ram,
Yonatan B. Tzur

Affiliations

Yisrael Rappaport: Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem
Hanna Achache: Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem
Roni Falk: Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem
Omer Murik: Medical Genetics Institute, Shaare Zedek Medical Center
Oren Ram: Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem
Yonatan B. Tzur: Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem

DOI: https://doi.org/10.1038/s41467-021-24815-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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During meiosis, sex chromosomes show silenced gene expression that is disrupted when translocated to autosomes. Here, the authors engineer C. elegans with bisected X chromosomes and see active transcription in gonads, indicating continuity of sex chromosomes promotes silencing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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