MpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO2 levels

Sook-Ha Fan; Patrick Ebner; Sebastian Reichert; Tobias Hertlein; Susanne Zabel; Aditya Kumar Lankapalli; Kay Nieselt; Knut Ohlsen; Friedrich Götz

doi:10.1038/s41467-019-11547-5

Nature Communications (Aug 2019)

MpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO2 levels

Sook-Ha Fan,
Patrick Ebner,
Sebastian Reichert,
Tobias Hertlein,
Susanne Zabel,
Aditya Kumar Lankapalli,
Kay Nieselt,
Knut Ohlsen,
Friedrich Götz

Affiliations

Sook-Ha Fan: Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen
Patrick Ebner: Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen
Sebastian Reichert: Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen
Tobias Hertlein: Institute for Molecular Infection Biology (IMIB), University of Würzburg
Susanne Zabel: Center for Bioinformatics Tübingen, University of Tübingen, Sand 14
Aditya Kumar Lankapalli: Department of Archaeogenetics, Max Planck Institute for the Science of Human History
Kay Nieselt: Center for Bioinformatics Tübingen, University of Tübingen, Sand 14
Knut Ohlsen: Institute for Molecular Infection Biology (IMIB), University of Würzburg
Friedrich Götz: Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen

DOI: https://doi.org/10.1038/s41467-019-11547-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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The mechanisms behind CO2 dependency in non-autotrophic bacterial isolates are unclear. Here the authors show that the Staphylococcus aureus mpsAB operon is crucial for growth at atmospheric CO2 levels, and provide evidence indicating that MpsAB represents a bicarbonate concentrating system.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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