Nature Communications (Apr 2017)
Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice
Abstract
Dystonia is thought to be driven by impairments in cerebellar signalling. The authors use a mouse genetic approach to silence excitatory transmission in the inferior olive to cerebellum pathway, resulting in dystonia-like signs in the animals which can be alleviated using DBS stimulation of the pathway.