Nature Communications (Apr 2017)

Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice

  • Joshua J. White,
  • Roy V. Sillitoe

DOI
https://doi.org/10.1038/ncomms14912
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 16

Abstract

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Dystonia is thought to be driven by impairments in cerebellar signalling. The authors use a mouse genetic approach to silence excitatory transmission in the inferior olive to cerebellum pathway, resulting in dystonia-like signs in the animals which can be alleviated using DBS stimulation of the pathway.