Dynamics of biochemical markers of systemic inflammatory response and renal functional condition in patients with myocardial infarction without ST elevation in the dependence of percutaneous angioplasty

Abstract

Aim. Assessment of the dynamics of biochemical markers and renal functional condition in patients with myocardial infarction without ST elevation, depending on the percutaneous angioplasty performed during 3 and 6 months of observation. Materials and methods. We examined 77 patients (63.6% of men) with myocardial infarction without ST elevation from age 50 to 79 (mean 64.1±1.0) years. All patients on the 3rd day of hospitalization and on the 3rd and 6th months of observation conducted a comprehensive assessment of biochemical markers of myocardial damage and renal functional condition. Results and Discussion. Analysis of the dynamics of biochemical markers of myocardial damage and the renal functional condition against the background of different therapies in patients with myocardial infarction without ST elevation demonstrated that in the invasive group, the level of troponin I during the 3 months of follow-up decreased by 549 times and during 6 months - by 2,200 times in comparison with the original value, which was accompanied by a decrease in the level of the indicator by 3 times. A significant decrease in the incidence of microalbuminuria was recorded in the group of invasive treatment at the 3rd and 6th months. In the non-invasive treatment group, a tendency to increase the frequency of these cases from 21.6% to 27.0% in the 3rd and 6th months Conclusions. Invasive treatment in the acute period of myocardial infarction without ST elevation, unlike non-invasive, is accompanied by a more convincing decrease in the level of necrosis-specific marker troponin I and more convincing renal-protective effect and inhibition of the development of cardiorenal syndrome, manifested by a significant decrease in the frequency of the registration of cases of microalbuminuria and an increase in the velocity of glomerular filtration for all periods of observation.

Keywords

• myocardial infarction without st elevation, biochemical markers, renal function