Nature Communications (Jan 2017)
A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance
- Babette C. Hammerling,
- Rita H. Najor,
- Melissa Q. Cortez,
- Sarah E. Shires,
- Leonardo J. Leon,
- Eileen R. Gonzalez,
- Daniela Boassa,
- Sébastien Phan,
- Andrea Thor,
- Rebecca E. Jimenez,
- Hong Li,
- Richard N. Kitsis,
- Gerald W. Dorn II,
- Junichi Sadoshima,
- Mark H. Ellisman,
- Åsa B. Gustafsson
Affiliations
- Babette C. Hammerling
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- Rita H. Najor
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- Melissa Q. Cortez
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- Sarah E. Shires
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- Leonardo J. Leon
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- Eileen R. Gonzalez
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- Daniela Boassa
- Center for Research in Biological Systems, National Center for Microscopy and Imaging Research, University of California San Diego
- Sébastien Phan
- Center for Research in Biological Systems, National Center for Microscopy and Imaging Research, University of California San Diego
- Andrea Thor
- Center for Research in Biological Systems, National Center for Microscopy and Imaging Research, University of California San Diego
- Rebecca E. Jimenez
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- Hong Li
- Rutgers New Jersey Medical School
- Richard N. Kitsis
- Albert Einstein College of Medicine
- Gerald W. Dorn II
- Washington University School of Medicine
- Junichi Sadoshima
- Rutgers New Jersey Medical School
- Mark H. Ellisman
- Center for Research in Biological Systems, National Center for Microscopy and Imaging Research, University of California San Diego
- Åsa B. Gustafsson
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- DOI
- https://doi.org/10.1038/ncomms14050
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Damaged mitochondria are normally cleared through canonical and alternative autophagy pathways. Here, the authors report that mitochondria can be cleared through an autophagy-independent endosomal-lysosomal pathway that depends on Parkin-dependent sequestration of mitochondria in Rab5-positive early endosomes.
