Symptomatic SARS-CoV-2 infections after full schedule BNT162b2 vaccination in seropositive healthcare workers: a case series from a single institution

Andreina Baj; Federica Novazzi; Angelo Genoni; Francesca Drago Ferrante; Stefano Taborelli; Beatrice Pini; Michele Partenope; Marilena Valli; Daniela Dalla Gasperina; Riccardo Capuano; Martina Prestia; Pietro Giorgio Spezia; Lorenzo Azzi; Daniele Focosi; Fabrizio Maggi

doi:10.1080/22221751.2021.1942230

Emerging Microbes and Infections (Jan 2021)

Symptomatic SARS-CoV-2 infections after full schedule BNT162b2 vaccination in seropositive healthcare workers: a case series from a single institution

Andreina Baj,
Federica Novazzi,
Angelo Genoni,
Francesca Drago Ferrante,
Stefano Taborelli,
Beatrice Pini,
Michele Partenope,
Marilena Valli,
Daniela Dalla Gasperina,
Riccardo Capuano,
Martina Prestia,
Pietro Giorgio Spezia,
Lorenzo Azzi,
Daniele Focosi,
Fabrizio Maggi

Affiliations

Andreina Baj: Department of Medicine and Surgery, University of Insubria, Varese, Italy
Federica Novazzi: Laboratory of Microbiology, ASST dei Sette Laghi, Varese, Italy
Angelo Genoni: Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy
Francesca Drago Ferrante: Laboratory of Microbiology, ASST dei Sette Laghi, Varese, Italy
Stefano Taborelli: Unit of Occupational Medicine, ASST dei Sette Laghi, Varese, Italy
Beatrice Pini: Clinical Pathology Unit, St. Anna Hospital, Como, Italy
Michele Partenope: Clinical Pathology Unit, St. Anna Hospital, Como, Italy
Marilena Valli: Clinical Pathology Unit, St. Anna Hospital, Como, Italy
Daniela Dalla Gasperina: Department of Medicine and Surgery, University of Insubria, Varese, Italy
Riccardo Capuano: Laboratory of Microbiology, ASST dei Sette Laghi, Varese, Italy
Martina Prestia: Laboratory of Microbiology, ASST dei Sette Laghi, Varese, Italy
Pietro Giorgio Spezia: Department of Translational Research, University of Pisa, Pisa, Italy
Lorenzo Azzi: Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Varese, Italy
Daniele Focosi: North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy
Fabrizio Maggi: Department of Medicine and Surgery, University of Insubria, Varese, Italy

DOI: https://doi.org/10.1080/22221751.2021.1942230
Journal volume & issue: Vol. 10, no. 1
pp. 1254 – 1256

Abstract

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We report 11 cases of SARS-CoV-2 infection in healthcare workers (HCW) naïve for COVID-19 and seropositive after the second dose of the BNT162b2 mRNA vaccine. Based on voluntary-based surveillance, they tested positive for different strains of SARS-CoV-2, as Spike gene sequencing showed. Five of them reported mild symptoms. Given the risk for SARS-CoV-2 introduction from asymptomatic vaccinees, this case series suggests the need to continue nasopharyngeal screening programmes.

Published in Emerging Microbes and Infections

ISSN: 2222-1751 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Science: Microbiology
Website: https://www.tandfonline.com/journals/temi

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Abstract

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