Efficiency of complex pig therapy with pathology of the distal department of the limbs
Abstract
Studies have been conducted to establish the dynamics of the course of treatment of purulent-inflammatory process of distal limb in pigs. The treatment algorithm was presented by two schemes: classic (I – experimental screw) and experimental (II – experimental group). Among the morphological parameters investigated: hemoglobin level, erythrocyte sedimentation rate (ESR), hematocrit, leukograms, total erythrocytes and leukocytes in the blood. To determine the immunobiological activity of the body of sick pigs, serum T: lymphocytes (CD2, CD3), T-helper cells (CD4), T-suppressors/killers (CD8), IRI (T-help/T-sup.), NK cells (CD16), B-lymphocytes (CD22), immunoglobulins A, M, G, CEC and phagocytic index. Research objectives – determining the effectiveness of treatment regimens algorithm for morphological and immunological composition of the blood in different forms of lymphoma disease distal extremities in pigs. Manifestation effector function was observed a decrease in lymphocytes, proliferation and differentiation of corresponding antibodies of the immune system of pigs. Inhibition of regulatory function in the inflammatory process reduces the mechanisms of formation of biologically active compounds “chemotaxis factor”, “transfer factor”, “phagocytosis factor”, migration of neutrophils and macrophages. The decrease in the concentration of NK cells in 2 times, with the pathology open wound, indicates a decrease in the process of opsonization (antibody-dependent cellular cytotoxicity) due to the lack of immune response to pathogens in the inflammatory cell. In abscesses, purulent pododermatitis and laminitis, NK cells decrease 1.5 times with the indirect manifestation of specific cytotoxic cells (B-lymphocytes, macrophages). It is determined that the drug “Trifuzol 1%” activates effector and reparative function of specific components of immune activity (T and B lymphocytes, population of T cells, NK cells). The results of these studies in the article thoroughly show the dynamics of changes in morphological and immunological status of pigs for diseases of the musculoskeletal system of the distal extremity. The results will facilitate the work of veterinary practitioners in the treatment of nosological forms of distal limb diseases in pigs.
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