Frontiers in Oncology (Dec 2022)

Metastatic mesenchymal chondrosarcoma showing a sustained response to cabozantinib: A case report

  • Veronika Blum,
  • Vanghelita Andrei,
  • Baptiste Ameline,
  • Silvia Hofer,
  • Bruno Fuchs,
  • Klaus Strobel,
  • Anna Allemann,
  • Beata Bode,
  • Daniel Baumhoer

DOI
https://doi.org/10.3389/fonc.2022.1086677
Journal volume & issue
Vol. 12

Abstract

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Mesenchymal chondrosarcoma is a rare and aggressive sarcoma subtype with high risk for distant metastases and poor prognosis. Currently NCCN- and ESMO-Guidelines recommend using Ewing sarcoma protocols as standard treatment. Nevertheless, in localized disease overall 5-year survival rates are below 50% whereas in metastatic spread median progression-free survival rates of only 5 months can be expected. Here we present a patient with metastatic osseous spread of mesenchymal chondrosarcoma that showed a sustained clinical improvement and a good partial response on imaging over a period of one year when treated with the multi-tyrosine kinase inhibitor cabozantinib. Although we cannot explain the exact mechanism underlying this treatment effect, tumors with similar genetic patterns might respond to the same therapy as well.

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