Interstitial Pneumonia in Psoriasis

Hironori Kawamoto, MD; Hiromichi Hara, MD; Shunsuke Minagawa, MD; Takanori Numata, MD; Jun Araya, MD; Yumi Kaneko, MD; Yoshinori Umezawa, MD; Akihiko Asahina, MD; Hidemi Nakagawa, MD; Kazuyoshi Kuwano, MD

Mayo Clinic Proceedings: Innovations, Quality & Outcomes (Dec 2018)

Interstitial Pneumonia in Psoriasis

Hironori Kawamoto, MD,
Hiromichi Hara, MD,
Shunsuke Minagawa, MD,
Takanori Numata, MD,
Jun Araya, MD,
Yumi Kaneko, MD,
Yoshinori Umezawa, MD,
Akihiko Asahina, MD,
Hidemi Nakagawa, MD,
Kazuyoshi Kuwano, MD

Affiliations

Hironori Kawamoto, MD: Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
Hiromichi Hara, MD: Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan; Correspondence: Address to Hiromichi Hara, MD, Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-ku, Tokyo 105-8461, Japan.
Shunsuke Minagawa, MD: Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
Takanori Numata, MD: Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
Jun Araya, MD: Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
Yumi Kaneko, MD: Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
Yoshinori Umezawa, MD: Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan
Akihiko Asahina, MD: Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan
Hidemi Nakagawa, MD: Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan
Kazuyoshi Kuwano, MD: Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan

Journal volume & issue: Vol. 2, no. 4
pp. 370 – 377

Abstract

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Objective: To investigate the relationship between psoriasis and interstitial pneumonia (IP). Patients and Methods: We analyzed the clinical data of patients with psoriasis treated with biologic agents from June 1, 2008, to June 30, 2017, retrospectively. Chest computed tomography was performed in 392 patients before treatment. The clinical characteristics and radiographic findings of these patients were evaluated. Results: Of the 392 patients with psoriasis, IP was detected in 8 patients (2%). Bilateral ground-glass and/or irregular linear (reticular) opacity in the lower lung zone was the most common chest computed tomography finding. Five of the 8 patients with IP were treated with anti–interleukin (IL) 12/IL-23 or IL-17 antibodies, leading to decreased or stable IP activity. Conclusion: Interstitial pneumonia was detected in 2% of patients with psoriasis who needed systemic treatments. Ground-glass and/or irregular linear (reticular) opacity in the bilateral lower lobes was characteristic of IP with psoriasis. The IL-23/IL-17 axis may play important roles in the pathogenesis of IP in psoriasis.

Published in Mayo Clinic Proceedings: Innovations, Quality & Outcomes

ISSN: 2542-4548 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General)
Website: https://www.journals.elsevier.com/mayo-clinic-proceedings-innovations-quality-and-outcomes/

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