The Light-Addressable Potentiometric Sensor and Its Application in Biomedicine towards Chemical and Biological Sensing

Yage Liu; Ping Zhu; Shuge Liu; Yating Chen; Dongxin Liang; Miaomiao Wang; Liping Du; Chunsheng Wu

doi:10.3390/chemosensors10050156

Chemosensors (Apr 2022)

The Light-Addressable Potentiometric Sensor and Its Application in Biomedicine towards Chemical and Biological Sensing

Yage Liu,
Ping Zhu,
Shuge Liu,
Yating Chen,
Dongxin Liang,
Miaomiao Wang,
Liping Du,
Chunsheng Wu

Affiliations

Yage Liu: Department of Biophysics, Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China
Ping Zhu: Department of Biophysics, Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China
Shuge Liu: Department of Biophysics, Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China
Yating Chen: Department of Biophysics, Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China
Dongxin Liang: Department of Biophysics, Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China
Miaomiao Wang: Department of Biophysics, Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China
Liping Du: Department of Biophysics, Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China
Chunsheng Wu: Department of Biophysics, Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China

DOI: https://doi.org/10.3390/chemosensors10050156
Journal volume & issue: Vol. 10, no. 5
p. 156

Abstract

Read online

The light-addressable potential sensor (LAPS) was invented in 1988 and has developed into a multi-functional platform for chemical and biological sensing in recent decades. Its surface can be flexibly divided into multiple regions or pixels through light addressability, and each of them can be sensed independently. By changing sensing materials and optical systems, the LAPS can measure different ions or molecules, and has been applied to the sensing of various chemical and biological molecules and cells. In this review, we firstly describe the basic principle of LAPS and the general configuration of a LAPS measurement system. Then, we outline the most recent applications of LAPS in chemical sensing, biosensing and cell monitoring. Finally, we enumerate and analyze the development trends of LAPS from the aspects of material and optical improvement, hoping to provide a research and application perspective for chemical sensing, biosensing and imaging technology.

Published in Chemosensors

ISSN: 2227-9040 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: http://www.mdpi.com/journal/chemosensors

About the journal

Abstract

Keywords