Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions

Ichrak Souii; Med Abderrahmane Sanhoury; Javier Vicario; Xabier Jiménez-Aberásturi; Mohamed L. Efrit; Hedi M’rabet; Jesús M. de los Santos

doi:10.3390/molecules28124678

Molecules (Jun 2023)

Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions

Ichrak Souii,
Med Abderrahmane Sanhoury,
Javier Vicario,
Xabier Jiménez-Aberásturi,
Mohamed L. Efrit,
Hedi M’rabet,
Jesús M. de los Santos

Affiliations

Ichrak Souii: Laboratory of Selective Organic & Heterocyclic Synthesis Biological Activity Evaluation (LR17ES01), Department of Chemistry, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia
Med Abderrahmane Sanhoury: Laboratory of Structural Organic Chemistry: Synthesis and Physicochemical Studies, Department of Chemistry, Faculty of Sciences of Tunis, University of Tunis El Manar, El Manar I, Tunis 2092, Tunisia
Javier Vicario: Department of Organic Chemistry I, Faculty of Pharmacy and Lascaray Research Center, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria, Spain
Xabier Jiménez-Aberásturi: Department of Organic Chemistry I, Faculty of Pharmacy and Lascaray Research Center, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria, Spain
Mohamed L. Efrit: Laboratory of Selective Organic & Heterocyclic Synthesis Biological Activity Evaluation (LR17ES01), Department of Chemistry, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia
Hedi M’rabet: Laboratory of Selective Organic & Heterocyclic Synthesis Biological Activity Evaluation (LR17ES01), Department of Chemistry, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia
Jesús M. de los Santos: Department of Organic Chemistry I, Faculty of Pharmacy and Lascaray Research Center, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria, Spain

DOI: https://doi.org/10.3390/molecules28124678
Journal volume & issue: Vol. 28, no. 12
p. 4678

Abstract

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Several bis(α-aminophosphonates) have been conveniently prepared in good yields using a straightforward multicomponent Kabachnik–Fields reaction between ethane 1,2-diamine or propane 1,3-diamine, diethylphosphite and aldehydes under catalyst-free conditions. The nucleophilic substitution reaction of bis(α-aminophosphonates) prepared and ethyl (2-bromomethyl)acrylate under mild reaction conditions afforded an original synthetic approach to a new series of bis(allylic-α-aminophosphonates).

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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