IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes

Olivia J. James; Maud Vandereyken; Julia M. Marchingo; Francois Singh; Susan E. Bray; Jamie Wilson; Andrew G. Love; Mahima Swamy

doi:10.1038/s41467-021-24473-2

Nature Communications (Jul 2021)

IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes

Olivia J. James,
Maud Vandereyken,
Julia M. Marchingo,
Francois Singh,
Susan E. Bray,
Jamie Wilson,
Andrew G. Love,
Mahima Swamy

Affiliations

Olivia J. James: MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee
Maud Vandereyken: MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee
Julia M. Marchingo: Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee
Francois Singh: MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee
Susan E. Bray: NHS Research Scotland, Tayside Tissue Biorepository, University of Dundee
Jamie Wilson: Department of Pathology, NHS Tayside, Ninewells Hospital
Andrew G. Love: MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee
Mahima Swamy: MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee

DOI: https://doi.org/10.1038/s41467-021-24473-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Intraepithelial lymphocytes (IEL) respond to IL-15 complexed with IL-15Ra but how this intrinsically affects IEL is unclear. Here the authors use proteomics analyses of the main mouse IEL subsets and identify PIM kinases as essential for IEL proliferation, metabolism and effector function downstream of IL-15.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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