Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6

Dae-Chul Cho; Holly J. Brennan; Rachelle W. Johnson; Ingrid J. Poulton; Jonathan H. Gooi; Brett A. Tonkin; Narelle E. McGregor; Emma C. Walker; David J. Handelsman; T. J. Martin; Natalie A. Sims

doi:10.1038/s41467-017-00920-x

Nature Communications (Oct 2017)

Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6

Dae-Chul Cho,
Holly J. Brennan,
Rachelle W. Johnson,
Ingrid J. Poulton,
Jonathan H. Gooi,
Brett A. Tonkin,
Narelle E. McGregor,
Emma C. Walker,
David J. Handelsman,
T. J. Martin,
Natalie A. Sims

Affiliations

Dae-Chul Cho: St. Vincent’s Institute of Medical Research
Holly J. Brennan: St. Vincent’s Institute of Medical Research
Rachelle W. Johnson: St. Vincent’s Institute of Medical Research
Ingrid J. Poulton: St. Vincent’s Institute of Medical Research
Jonathan H. Gooi: Department of Medicine at St. Vincent’s Hospital, University of Melbourne
Brett A. Tonkin: St. Vincent’s Institute of Medical Research
Narelle E. McGregor: St. Vincent’s Institute of Medical Research
Emma C. Walker: St. Vincent’s Institute of Medical Research
David J. Handelsman: Department of Andrology, ANZAC Research Institute, University of Sydney
T. J. Martin: St. Vincent’s Institute of Medical Research
Natalie A. Sims: St. Vincent’s Institute of Medical Research

DOI: https://doi.org/10.1038/s41467-017-00920-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

The strength of long bones is determined by coalescence of trabeculae during corticalization. Here the authors show that this process is regulated by SOCS3 via a mechanism dependent on IL-6 and expression of sex hormones.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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