Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice

Alexandra J. Spencer; Paul F. McKay; Sandra Belij-Rammerstorfer; Marta Ulaszewska; Cameron D. Bissett; Kai Hu; Karnyart Samnuan; Anna K. Blakney; Daniel Wright; Hannah R. Sharpe; Ciaran Gilbride; Adam Truby; Elizabeth R. Allen; Sarah C. Gilbert; Robin J. Shattock; Teresa Lambe

doi:10.1038/s41467-021-23173-1

Nature Communications (May 2021)

Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice

Alexandra J. Spencer,
Paul F. McKay,
Sandra Belij-Rammerstorfer,
Marta Ulaszewska,
Cameron D. Bissett,
Kai Hu,
Karnyart Samnuan,
Anna K. Blakney,
Daniel Wright,
Hannah R. Sharpe,
Ciaran Gilbride,
Adam Truby,
Elizabeth R. Allen,
Sarah C. Gilbert,
Robin J. Shattock,
Teresa Lambe

Affiliations

Alexandra J. Spencer: Nuffield Department of Medicine, The Jenner Institute, University of Oxford
Paul F. McKay: Department of Infectious Disease, Imperial College London
Sandra Belij-Rammerstorfer: Nuffield Department of Medicine, The Jenner Institute, University of Oxford
Marta Ulaszewska: Nuffield Department of Medicine, The Jenner Institute, University of Oxford
Cameron D. Bissett: Nuffield Department of Medicine, The Jenner Institute, University of Oxford
Kai Hu: Department of Infectious Disease, Imperial College London
Karnyart Samnuan: Department of Infectious Disease, Imperial College London
Anna K. Blakney: Department of Infectious Disease, Imperial College London
Daniel Wright: Nuffield Department of Medicine, The Jenner Institute, University of Oxford
Hannah R. Sharpe: Nuffield Department of Medicine, The Jenner Institute, University of Oxford
Ciaran Gilbride: Nuffield Department of Medicine, The Jenner Institute, University of Oxford
Adam Truby: Nuffield Department of Medicine, The Jenner Institute, University of Oxford
Elizabeth R. Allen: Nuffield Department of Medicine, The Jenner Institute, University of Oxford
Sarah C. Gilbert: Nuffield Department of Medicine, The Jenner Institute, University of Oxford
Robin J. Shattock: Department of Infectious Disease, Imperial College London
Teresa Lambe: Nuffield Department of Medicine, The Jenner Institute, University of Oxford

DOI: https://doi.org/10.1038/s41467-021-23173-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 8

Abstract

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Heterologous vaccination regimens for COVID-19 could be useful for example if there is a shortage of one vaccine type. Here, Spencer et al. show that heterologous vaccination with a self-amplifying RNA vaccine and an adenoviral vectored vaccine performs at least as well as the homologous vaccinations in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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