Flexible simultaneous mesoscale two-photon imaging of neural activity at high speeds

Mitchell Clough; Ichun Anderson Chen; Seong-Wook Park; Allison M. Ahrens; Jeffrey N. Stirman; Spencer L. Smith; Jerry L. Chen

doi:10.1038/s41467-021-26737-3

Nature Communications (Nov 2021)

Flexible simultaneous mesoscale two-photon imaging of neural activity at high speeds

Mitchell Clough,
Ichun Anderson Chen,
Seong-Wook Park,
Allison M. Ahrens,
Jeffrey N. Stirman,
Spencer L. Smith,
Jerry L. Chen

Affiliations

Mitchell Clough: Department of Biomedical Engineering, Boston University
Ichun Anderson Chen: Department of Biomedical Engineering, Boston University
Seong-Wook Park: Department of Biomedical Engineering, Boston University
Allison M. Ahrens: Department of Biology, Boston University
Jeffrey N. Stirman: Neuroscience Center, University of North Carolina School of Medicine
Spencer L. Smith: Department of Electrical and Computer Engineering, University of California Santa Barbara
Jerry L. Chen: Department of Biomedical Engineering, Boston University

DOI: https://doi.org/10.1038/s41467-021-26737-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 7

Abstract

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Functional brain imaging with two-photon microscopy is limited by a tradeoff between imaging area and acquisition speed. Here, the authors present Quadroscope, a flexible microscope which allows for simultaneous video rate acquisition of four independently targetable brain regions across 5 mm.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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