Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron

Hejun Liu; Chengzi I. Kaku; Ge Song; Meng Yuan; Raiees Andrabi; Dennis R. Burton; Laura M. Walker; Ian A. Wilson

doi:10.1038/s42003-022-03700-6

Communications Biology (Jul 2022)

Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron

Hejun Liu,
Chengzi I. Kaku,
Ge Song,
Meng Yuan,
Raiees Andrabi,
Dennis R. Burton,
Laura M. Walker,
Ian A. Wilson

Affiliations

Hejun Liu: Department of Integrative Structural and Computational Biology, The Scripps Research Institute
Chengzi I. Kaku: Adimab, LLC
Ge Song: Department of Immunology and Microbiology, The Scripps Research Institute
Meng Yuan: Department of Integrative Structural and Computational Biology, The Scripps Research Institute
Raiees Andrabi: Department of Immunology and Microbiology, The Scripps Research Institute
Dennis R. Burton: Department of Immunology and Microbiology, The Scripps Research Institute
Laura M. Walker: Adimab, LLC
Ian A. Wilson: Department of Integrative Structural and Computational Biology, The Scripps Research Institute

DOI: https://doi.org/10.1038/s42003-022-03700-6
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Structural and computational analyses reveal a recurring YYDRxG motif in a class of human antibodies that target a conserved epitope on sarbecoviruses including the Omicron variant.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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