Allogeneic hematopoietic stem cell transplant for HIV patient's plasmablastic lymphoma: Case report

Abstract

Given the scarcity of data available on Plasmablastic lymphoma (PBL) and human immunodeficiency virus (HIV) patients undergoing allogeneic hematopoietic stem cell transplant (Allo-HSCT), we share our experience. We review the barriers overcome by the patient with regards to their diagnosis, treatment, and transplant. We describe challenges encountered when considering Allo-HSCT persons with HIV and PBL. Most significant to the patient was the use of a donor with HIV resistant mutation, homozygous CCR5Δ32/Δ32. Therefore, we pursued transplant with a mismatched unrelated donor (MMUD) to meet patient's desire of a possible HIV cure. We explore the unique approaches and difficulties in treating PBL. Despite post-transplant complications, including early relapse, patient achieved complete remission (CR) by day+100 with a preserved donor graft and undetected viral loads nearing the one-year milestone.

Keywords

• Plasmablastic lymphoma (PBL)
• Human immunodeficiency virus (HIV)
• Allogeneic hematopoietic stem cell transplant (Allo-HSCT)
• Case report