ASPECTS CONCERNING THE EFFECT OF SOME ANTIOXIDANTS ON LIVER HISTOLOGICAL STRUCTURE IN WEANED PIGS, INTOXICATED WITH DEOXYNIVALENOL (DON)

Abstract

Deoxynivalenol is a mycotoxin produced by fungi of the Fusarium genera, which are abundant in various cereal crops and processed grains. In order to protect cell structure within the tissues studied, we tried various experimental variants by incorporating some selenium and boron sources into the combined fodder, and also in mixture with DON with different concentrations. To determine the morphophysiological changes induced by the mycotoxin DON upon liver histological structure, and also the antioxidants’ effects, we took samples from 9 piglets belonging to three groups: group 1 (fed with fodder added with DON), group 2 (fed with fodder added with selenium) and group 3 (fed with fodder added with selenium and DON). In the case of the individuals in groups 2 and 3 fed with fodder added with addition of selenium, respectively of DON and selenium, the microscopic images reveal the presence of uniform hepatic lobules, delimited between them through fine conjunctive septa. The intralobular capillary network is hypertrophic. The selenium added in the fodder for the individuals from group 3 has a hepatoprotective role, aspect suggested by dystrophic processes occurred on small areas, caused by the presence of DON and by the vascular network’s hypertrophy. In the case of this group, we observed a strong stimulation on the defense system, suggested by the presence of the leukocyte infiltrates within the interlobular conjunctive and by the vascular network’s hypertrophy.

Keywords

• fusarium
• deoxynivalenol
• liver
• histology modifications
• pig
• antioxidant
• selenium