Nature Communications (Oct 2022)
Endothelial alpha globin is a nitrite reductase
- T. C. Stevenson Keller,
- Christophe Lechauve,
- Alexander S. Keller,
- Gilson Brás Broseghini-Filho,
- Joshua T. Butcher,
- Henry R. Askew Page,
- Aditi Islam,
- Zhe Yin Tan,
- Leon J. DeLalio,
- Steven Brooks,
- Poonam Sharma,
- Kwangseok Hong,
- Wenhao Xu,
- Alessandra Simão Padilha,
- Claire A. Ruddiman,
- Angela K. Best,
- Edgar Macal,
- Daniel B. Kim-Shapiro,
- George Christ,
- Zhen Yan,
- Miriam M. Cortese-Krott,
- Karina Ricart,
- Rakesh Patel,
- Timothy P. Bender,
- Swapnil K. Sonkusare,
- Mitchell J. Weiss,
- Hans Ackerman,
- Linda Columbus,
- Brant E. Isakson
Affiliations
- T. C. Stevenson Keller
- Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Christophe Lechauve
- Department of Hematology, St. Jude Children’s Research Hospital
- Alexander S. Keller
- Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Gilson Brás Broseghini-Filho
- Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Joshua T. Butcher
- Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University
- Henry R. Askew Page
- Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Aditi Islam
- Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Zhe Yin Tan
- Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Leon J. DeLalio
- Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Steven Brooks
- Physiology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases
- Poonam Sharma
- Department of Biomedical Engineering, University of Virginia
- Kwangseok Hong
- Department of Physical Education, College of Education, Chung-Ang University
- Wenhao Xu
- Transgenic Mouse Facility, Department of Medicine, University of Virginia School of Medicine
- Alessandra Simão Padilha
- Department of Physiological Sciences, Federal University of Espirito Santo
- Claire A. Ruddiman
- Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Angela K. Best
- Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Edgar Macal
- Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Daniel B. Kim-Shapiro
- Department of Physics, Translational Science Center, Wake Forest University
- George Christ
- Department of Biomedical Engineering, University of Virginia
- Zhen Yan
- Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Miriam M. Cortese-Krott
- Cardiovascular Research Laboratory, Division of Cardiology, Pneumology and Angiology, Medical Faculty, Heinrich Heine University
- Karina Ricart
- Department of Pathology, University of Alabama at Birmingham
- Rakesh Patel
- Department of Pathology, University of Alabama at Birmingham
- Timothy P. Bender
- Department of Microbiology, Immunology and Cancer, University of Virginia School of Medicine
- Swapnil K. Sonkusare
- Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Mitchell J. Weiss
- Department of Hematology, St. Jude Children’s Research Hospital
- Hans Ackerman
- Physiology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases
- Linda Columbus
- Department of Molecular Physiology and Biophysics, University of Virginia School of Medicine
- Brant E. Isakson
- Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-34154-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
In mammals, hypoxia causes dilation of small arteries for increased metabolic demand. Keller et al used novel transgenic mice to show alpha hemoglobin in endothelium, once thought only in red blood cells, can regulate hypoxic-mediated dilation.
