Immunological factors of cardiovascular risk (TNF-α) depending on various hemodynamic forms of arterial hypertension in adolescents.

Abstract

119 children aged 12-17 years with the stable and labile forms of arterial hypertension (AH) and prehypertension hospitalized to cardiopulmonary department due to ambulatory single-measured blood pressure (BP) elevation were observed. The level of TNF-α in adolescents with different forms of AH and prehypertension as well as the correlation of this marker with other cardiovascular risk factors was determined. There was a significant increase in the mean value (9.50±0.54 pg/ml) and frequency (45.6%) of increase of TNF-α level in the group of children with AH compared with the group of children with normotension (6.43±0,64 pg/ml and 12.5% respectively). There is shown a tendency to increase of TNF-α levels, depending on the degree of stabilization of AH with the highest level of proinflammatory cytokines of TNF-α in the group of children with stable systolic BP. The positive correlation of TNF-α with the daily BP monitoring indicators, especially with the level of diastolic BP and its variability at night was revealed.

Keywords

• arterial hypertension
• tumor necrosis factor-α
• risk factors
• adolescents