Проблемы особо опасных инфекций (Aug 2012)
Phenotypic and Molecular-Genetic Analysis of Genetically Modified Toxigenic <I>Vibrio cholerae</I> El Tor Strain 301, Isolated in 2011 in Russia
Abstract
The phenotypic and molecular-genetic analysis of Vibrio cholerae O1 El Tor Inaba strain 301, isolated in 2011 from sea water in recreation zone in Taganrog, demonstrated this isolate to be a genetic variant of El Tor cholera causative agent. Its genome was shown to carry a hybrid prophage, containing gene ctxB of classical type and gene rstR of El Tor type, as well as altered pathogenicity island VPI-1 and pandemicity island VSP-II. This strain produced much more cholera toxin (0,12 mcg/ml) than typical strains of this causative agent.
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